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This book is unique for its comprehensive presentation of protease function in the stomach, colon, pancreas and liver under both physiological conditions and major diseases manifesting in these four organs. The individual chapters have been written by leaders in the field who outline in great detail the role of proteases in the pathogenesis, diagnosis and treatment of disease.
Available animal models (of disease, transgenic, or knock-out) are extensively referred to and experimental data obtained thereby are discussed in the context of patient-derived data.
Newcomers to the field and interested non-specialists will take advantage of the extensive introduction to individual proteases, protease families, and the diseases. Understanding is greatly facilitated by the clear and condensed presentation of summarised data in tables and graphs. This book is a valuable source for both clinicians and basic and clinical researchers interested in protease function and/or diseases in gastrointestinal tissues.
Contributing Authors Preface Chapter 1 Protease-Activated Receptors in Gastrointestinal Function and Disease Nigel W. Bunnett and Graeme S. Cottrell Chapter 2 Matrix Metalloproteinases in Gastric Cancer Nikhil I. Khushalani and Nithya Ramnath Chapter 3 Proteases in Helicobacter pylori-Mediated Diseases Thomas Wex, Michael Zack, and Peter Malfertheiner Chapter 4 Proteases in Pancreatic Disease Avinash Sewpaul, Jeremy J. French, and Richard M. Charnley Chapter 5 PAR in the Pathogenesis of Pain in Pancreatic Disease Pankaj J. Pasricha Chapter 6 Importance of the Local Renin-Angiotensin System in Pancreatic Disease Po Sing Leung Chapter 7 Hepatitis C Viral Proteases And Inhibitors Mingjun Huang, Avinash Phadke and Atul Agarwal Chapter 8 Angiotensin Converting Enzyme in the Pathophysiology of Liver Fibrosis Yao Hong Wie Chapter 9 Matrix Metalloproteinases in Chronic Liver Disease and Liver Transplantation Hein W. Verspaget, Johan P. Kuyvenhoven, Cornelis F. M. Sier, Bart van Hoek Chapter 10 MMPs and ADAMs in Inflammatory Bowel Disease Alicja Wiercinska-Drapalo, Jerzy Jaroszewicz, Anna Parfieniuk, Anna Moniuszko Chapter 11 Chemokines and Matrix Metalloproteinases in Colorectal Cancer Gayle G. Vaday and Stanley Zucker Chapter 12 Angiotensin-Converting Enzyme (ACE) in Gut Inflammation Fernando Magro Chapter 13 Intestinal Apical Protein Transport in Health and Disease Stephan von Hörsten, Michael Krahn, Nadine Frerker, Anja Gemeinhardt, Dennis Schwab, Silvia Slesiona, Hassan Naim, and Marwan Alfalah Index