Type 1 Diabetes

1. Front Matter

   Pages i-xiii

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2. Etiology

   1. Front Matter

      Pages 1-1

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   2. Epidemiology of Type 1 Diabetes

      • Janice S. Dorman, Ronald E. LaPorte, Thomas J. Songer

      Pages 3-22

   3. Genetics of Type 1 Diabetes

      • Massimo Pietropaolo, Massimo Trucco

      Pages 23-54

   4. Prediction and Prevention of Type 1 Diabetes

      • Aristides K. Maniatis, George S. Eisenbarth

      Pages 55-70

   5. Molecular Biology of β-Cell Destruction by Autoimmune Processes

      • Åke Lernmark, Choon Hee Chung

      Pages 71-92

   6. Type 1 Diabetes in Autoimmune Syndromes

      • Tiinamaija Tuomi, Jaakko Perheentupa

      Pages 93-114

   7. The Metabolic Basis of Insulin Secretion

      • Nicolai M. Doliba, Franz M. Matschinsky

      Pages 115-144

   8. Prevention and Correction of Hypoglycemia

      • Philip E. Cryer

      Pages 145-161

   9. Nonautoimmune Forms of Diabetes

      • Timothy G. Barrett

      Pages 163-179

3. Treatment of Type 1 Diabetes

   1. Front Matter

      Pages 181-181

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   2. Diabetic Ketoacidosis

      • Ram K. Menon, Mark A. Sperling

      Pages 183-198

   3. Insulin Regimens for Type 1 Diabetes

      • Baiju R. Shah, Bernard Zinman

      Pages 199-213

   4. Relationship Between Metabolic Control and Complications in Diabetes

      • Saul Genuth

      Pages 215-232

   5. Open- and Closed-Loop Insulin Delivery Systems and Glucose Sensors

      • John C. Pickup

      Pages 233-247

   6. Living with Diabetes

      • Jean Betschart Roemer, Linda Siminerio

      Pages 249-260

   7. Nutritional Management in Type 1 Diabetes

      • Christine A. Beebe

      Pages 261-276

4. Special Management Issues in Type 1 Diabetes

   1. Front Matter

      Pages 277-277

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   2. Special Problems and Management of the Child Less Than 5 Years of Age

      • Nadia Tubiana-Rufi, Paul Czernichow

      Pages 279-292

   3. The Preadolescent Child with Type 1 Diabetes

      • William V. Tamborlane, Elizabeth A. Boland, Margaret Grey

      Pages 293-305

A concise survey by physicians and researchers of the latest thinking about the causes of diabetes and the best approaches to treating its acute and chronic complications. The authors pay special attention to explaining the molecular basis of diabetes and its complications, as well as to the many recent developments in whole pancreas and islet cell transplantation, including the means for avoiding the rejection of transplanted islets.

• Diabetes
• Insulin Secretion
• Pancreas
• growth factor
• insulin
• metabolic control

"The first section provides a sound discussion of our understanding of the etiology of the disease, providing the reader with an excellent working knowledge to assess possible future prevention strategies. The clinical chapters are well organized, authored by known experts, and provide excellent summaries of cutting edge management. The final chapters devoted to islet transplantation and the relevant scientific issues are timely and enlightening...This entry in the Contemporary Endocrinology series represents a uniquely accessible overview of the current scientific and clinical frontiers relevant to type 1 diabetes mellitus. By providing an understanding of where immunological knowledge will likely lead and what current therapy should entail, this book provides an opportunity for both clinical and research specialists to better understand each other's fields." -Doody's Health Sciences Book Review Journal

"A highly recommended book that is hard to put down. It was easy to read, detailed, and extremely useful in a practical sense for clinicians." - E-Streams

"The complex interactions of genetics, autoimmunity, and insulin secretion are covered thoroughly and would gainfully challenge most experts in the field." -Annals of Internal Medicine

• Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, USA

  Mark A. Sperling

• Division of Endocrinology, Children’s Hospital of Pittsburgh, Pittsburgh, USA

  Mark A. Sperling

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