Hormones and the Heart in Health and Disease

1. Front Matter

   Pages i-x

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2. Natriuretic Peptides and the Heart

   • David G. Gardner, Branka Kovacic-Milivojevic, Faquan Liang, Songcang Chen

   Pages 1-20

3. Adrenomedullin and the Heart

   • Willis K. Samson

   Pages 21-38

4. Cardiac and Vascular Actions of Urocortin

   • David G. Parkes, Clive N. May

   Pages 39-52

5. The Renin-Angiotensin System and the Heart

   • Haralambos Gavras, Irene Gavras

   Pages 53-67

6. Adrenocortical Hormones and the Heart

   • Celso E. Gomez-Sanchez

   Pages 69-79

7. Catecholamines and the Heart

   • Matthew N. Levy

   Pages 81-101

8. Vasopressin and the Heart

   • Vernon S. Bishop, Max G. Sanderford

   Pages 103-113

9. Insulin and the Heart

   • Roger W Brownsey, Brian Rodrigues, Subodh Verma, John H. McNeill

   Pages 115-135

10. Kinins in the Heart

    • Oscar A. Carretero

    Pages 137-158

11. Endothelin and the Heart

    • David P. Brooks, Eliot H. Ohlstein

    Pages 159-174

12. Nitric Oxide and the Heart

    • Robert D. Bernstein, Fabio A. Recchia, Gabor Kaley, Thomas H. Hintze

    Pages 175-193

13. Contribution of Eicosanoids in the Heart

    • Kafait U. Malik

    Pages 195-218

14. Estrogen and the Heart

    • Jay M. Sullivan

    Pages 219-233

15. Androgen and Estrogen Effects on Plasma Lipids in Men

    • Carrie J. Bagatell, William J. Bremner

    Pages 235-251

16. Back Matter

    Pages 253-258

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The maintenance of arterial blood pressure and the distribution of blood flow to the various organs of the body depends on the control of the pumping action of the heart and of the resistance of the vascular beds in the individual organs in accordance with their metabolic needs. These controls are achieved through the integrated actions of circulat­ ing hormones, humoral factors that are synthesized and released in the heart and blood vessels, and the autonomic nervous system. The heart, however, is not only the target for the direct and indirect actions of a number of hormones and humoral factors, it is also an endocrine organ in the traditional sense, synthesizing and secreting into the circulation chemical factors that act at distant sites. In this treatise, Hormones and the Heart in Health and Disease, we interpret "endocrinology" broadly and consider traditional hormones as well as autocoids that are secreted by the heart or that act on it. In this overview, the relevant chapters are indicated in parentheses. The discovery of atrial natriuretic peptide (ANP; atrial natriuretic factor, ANF) in the 1980s indicated that the heart does indeed function as an endocrine organ in the classic sense. ANP (Chapter I) is synthesized in the heart and secreted into the circulation for actions on the kidney, where it is a potent natriuretic agent, and on the vasculature, where it causes vasodilation. ANP can also affect myocardial contractility.

• aldosterone
• blood vessel
• cardiovascular
• endothelium
• insulin
• pathophysiology
• physiology

"Each of the contributors is an acknowledged expert in the field and the chapters are carefully prepared and contain sufficient citations to make these contributions of reference value. . .The comprehensive nature of the book is further supported by the review of renin-angiotensin, endothelin, and insulin. . . I find this book to be useful as a reference source and also for its completeness. "-Doody's Health Sciences Book Review Journal

• Department of Physiology, The University of Tennessee, Memphis, USA

  Leonard Share

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