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In Molecular and Cellular Pediatric Endocrinology, Stuart Handwerger, MD and a distinguished panel of clinicians and experts review the most significant recent developments in molecular and cellular biology, powerful advances that have produced new diagnostic methods and improved treatments for many pediatric endocrine diseases. Topics range from the growth hormone/prolactin/placental lactogen gene family and their regulation of growth, to steroid hormones, sexual development, and mineral corticoid action. Additional chapters examine the pathophysiology of insulin-dependent diabetes mellitus, the molecular genetics of thyroid cancer, the molecular basis of hypophosphatemic rickets, and inherited diabetes insipidus.
Molecular and Cellular Pediatric Endocrinology offers today's clinicians and researchers not only the latest findings on endocrine disorders in their pediatric manifestations, but also highly practical insights into today's cutting-edge diagnostics, emerging treatment strategies, and powerful new therapeutics.
Molecular Basis of Disorders of Sexual Differentiation, G. D. Berkovitz and T. Seeherunovong. Insulin-Like Growth Factor Control of Growth: Insights from Targeted Disruption of Murine Genes and from Human Disease, S. D. Chernausek. Molecular Defects in the Growth Hormone Axis, J. D. Cogan and J. A. Phillips III. The Molecular Basis of Hypophosphatemic Rickets, M. J. Econs and T. M. Strom. The Roles of Growth Hormone, Prolactin, and Placental Lactogen in Human Fetal Development: Critical Analysis of Molecular, Cellular, and Clinical Investigations, M. Freemark. Growth Hormone Releasing Hormone: Biological and Molecular Aspects, P. L. Hofman and O. H. Pescovitz. The Glomerular Physiology of the Diabetic Nephropathy, D. J. Klein. P450c17- The Qualitative Regulator of Steroidogenesis, W. L. Miller. The Molecular Basis of Inherited Diabetes Insipidus, D. R. Repaske. Molecular Biology of Gonadotropin-Releasing Hormone and the Gonadotropin-Releasing Hormone Receptor, D. I. Shulman and B. B. Bercu. Estrogen Biology: Evolving New Concepts, E. P. Smith. Molecular Genetics of Thyroid Cancer: Evidence That Inactivation of Tumor Suppressor Genes Occurs at Late Stages of Tumor Progression, L. S. Ward and J. A. Fagin. The Molecular Basis of Mineralocorticoid Action, P. C. White. Molecular Aspects of Pituitary Development, P. S. Zeitler and C. A. Pickett. Physiology and Molecular Biology of Placental Lactogen in Human Pregnancy, R. G. Richards and S. Handwerger. Molecular and Cellular Basis of Immune-Mediated (Type 1) Diabetes, R. Coutant and N. K. MacLaren. Molecular Basis of Multiple Pituitary Hormone Deficiency, J. S. Parks and M. R. Brown. Index.