These comprehensive yet concise collections of articles by world experts survey the latest findings on the molecular biology of diabetes and insulin action and synthesize a coherent understanding of the subject. Topics include the etiology of type I and type II diabetes, molecular and cellular aspects of insulin action, and the mechanism of the insulin-stimulated glucose uptake.
Section I: Molecular and Cellular Aspects of Insulin Action. Mutations in the Insulin Receptor Gene in Patients with Genetic Syndromes of Extreme Insulin Resistance. The Insulin Receptor: Structure/Function Relationship. Identification of Diabetes-Related Genes by Subtraction Cloning. The Insulin Receptor-Related. Structure of Insulin Receptor Substrate 1 and Role in Insulin Signaling as a Docking Protein for SH2 Domain-Containing Proteins. Phosphatidylinositol 3'-Kinase and Insulin Action. The Role of p21ras in Insulin Signaling. MAP Kinase Pathways and Insulin Action. Raf-1 Kinase. Role of Phosphoprotein Phosphatase 1 (PP-1) in the Mechanism of Insulin Action. The Role (or Lack Thereof) of Protein Kinase C in Insulin Action. Regulation of the Phosphoenolpyruvate Carboxykinase Gene by Insulin. Regulation of Gene 33 Expression by Insulin. Distinct Elements in the PEPCK and Amylase Genes Mediate the Diabetes and Carbohydrate Response: Potential Role of IRE-ABP in Mediating the Dietary Response. Molecular Aspects of Insulin-Regulated Hepatic Growth. Endocytosis and Cellular Processing of Insulin-Receptor Complexes: Mechanisms and Biological Functions. Chiroinositol Deficiency and Insulin Resistance: A Clinical Perspective. Regulation of c-fos Gene Expression by Insulin in Neurons. Molecular Comparison of the Insulin and IGF-I Receptors. Insulin-Like Growth Factor-I and Insulin-Like Growth Factor Binding Proteins in Diabetes. Structure-Function Properties of Insulin/IGF-I Hybrid Receptors. Section II: Molecular Mechanisms of the Insulin-Regulatable Glucose Transport. GLUT-4 Glucose Transporters and Insulin Action in Humans: Regulation at the Level of Gene Expression and Cellular Trafficking. Mutant GLUT-4 and the Role of GLUT-4 Phosphorylation in Controlling Glucose Transport. GLUT-4 Phosphorylation: Effects of Phosphorylation on Glucose Transport and Intrinsic Activity. Glucose Transporters of Muscle Cells in Culture: Developmental Regulation and Modulation by Lipoic Acid, an Anti-Hyperglycemic Agent. Expression of the GLUT-4 Glucose Transporter in Diabetes. Index.