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Lessons from Animal Diabetes VI

75th Anniversary of the Insulin Discovery

  • Book
  • © 1996

Overview

Editors:
  1. Eleazar Shafrir

    1. Department of Biochemistry, Hadassah Medical Center, Jerusalem, Israel

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Part of the book series: Rev.Ser.Advs.Research Diab.Animals (Birkhäuser) (RSARDA, volume 6)

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Table of contents (23 chapters)

  1. Front Matter

    Pages i-xiii
    Download chapter PDF

  2. Insulin Dependent Diabetes; B-Cell Function; B-Cell Destruction Mechanisms

    1. Expression of glutamic acid decarboxylase (GAD) and its role as an autoantigen in insulin-dependent diabetes

      • Beverly E. Faulkner-Jones, Michelle B. French, Robert S. Schmidli, Susan Williamson, David S. Cram, Margo C. Honeyman et al.
      Pages 1-32

    2. Molecular genetics of insulin-dependent diabetes mellitus: Analysis of congenic strains

      • Hiroshi Ikegami, Susumu Makino, Toshio Ogihara
      Pages 33-46

    3. Role of macrophages and cytokines in B-cell death

      • Antje Faust, Rainer Kleemann, Helga Rothe, Hubert Kolb
      Pages 47-56

    4. Immunotherapy of insulin-dependent diabetes mellitus: Tolerance after short-term anti—;IL-2 receptor/cyclosporine therapy in BB/OK rats

      • Beate Kuttler, Silke Lucke, Lutz Vogt, Ingrid Klöting, Tibor Diamanstein, Hans-Jürgen Hahn
      Pages 57-76

    5. Role of retroviruses in the pathogenesis of diabetes with emphasis on the NOD mouse

      • Toshiaki Hanafusa, Koji Tomita, Hiromu Nakajima, Chisa Nakagawa, Jun-Ichiro Miyagawa, Masamichi Kuwajima et al.
      Pages 77-82

    6. Occurrence of pretype I diabetes (pre-IDDM) and type II diabetes (NIDDM) in BC1 [(NOD x Mus spretus) F1 x NOD] mice

      • Masakazu Hattori, Eiji Yamato, Eisaku Matsumoto, Naoto Itoh, Tetsushi Toyonaga, Maria Petruzzelli et al.
      Pages 83-95

    7. Okamoto model for B-cell damage: Recent advances

      • Hiroshi Okamoto
      Pages 97-111

    8. Alloxan derivatives as a tool for the elucidation of the mechanism of the diabetogenic action of alloxan

      • Sigurd Lenzen, Markus Tiedge, Anne Jörns, Rex Munday
      Pages 113-122

  3. Transgenic Animals in Diabetes Research

    1. Role of glucokinase in regulation of insulin secretion: Lessons from transgenic mice

      • Shimon Efrat
      Pages 123-130

    2. Consequences of human IAPP expression in transgenic mice

      • C. Bruce Verchere, David A. D’Alessio, Steven E. Kahn
      Pages 131-148

    3. Immunostimulatory versus immunosuppressive roles of IL-10 in IDDM: Analysis with IL-10—Producing transgenic NOD mice

      • Mitsuo Itakura, Maki Moritani, Katsuhiko Yoshimoto, Chikara Hashimoto, Satoshi Otsuka, Toshiaki Sano et al.
      Pages 149-173

    4. Polyol accumulation versus diabetic retinopathy and nephropathy in transgenic mice expressing human aldose reductase

      • Mitsuo Itakura, Setsuko II, Mika Ohta, Takashi Yamaoka
      Pages 175-200

    5. Transgenic hyperinsulinemia: A mouse model of insulin resistance and glucose intolerance without obesity

      • S. Lee Marbán, Jesse Roth
      Pages 201-224

  4. Non-Insulin-Dependent Diabetes: New Models and Update on Existing Models. Diabetes Complications and Therapeutic Modalities

    1. Spontaneously diabetic rat “OLETF” as a model for NIDDM in humans

      • Kazuya Kawano, Tsukasa Hirashima, Shigehito Mori, Takashi Natori
      Pages 225-236

    2. Glucose and lipid metabolism in the gold thioglucose injected mouse model of diabesity

      • Stephen C. Blair, Ian D. Caterson, Gregory J. Cooney
      Pages 237-265

    3. Diabetes in the Chinese hamster

      • Barbara J. Frankel
      Pages 267-298

    4. Studies on the pathogenesis of NIDDM in the GK (Goto-Kakizaki) rat

      • Claes-Göran Östenson, Samy M. Abdel-Halim, Arne Andersson, Suad Efendic
      Pages 299-315

    5. Role of immune and non-immune aspects of genetics in different expressions of diabetes in db/db mice

      • Konstantin Bloch, Pnina Vardi
      Pages 317-332

    6. Inositols—Potential roles in insulin action and in diabetes: Evidence from insulin-resistant nonhuman primates

      • Barbara C. Hansen, Heidi K. Ortmeyer
      Pages 333-348
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Keywords

Editors and Affiliations

  • Department of Biochemistry, Hadassah Medical Center, Jerusalem, Israel

    Eleazar Shafrir

Bibliographic Information

  • Book Title: Lessons from Animal Diabetes VI

  • Book Subtitle: 75th Anniversary of the Insulin Discovery

  • Editors: Eleazar Shafrir

  • Series Title: Rev.Ser.Advs.Research Diab.Animals (Birkhäuser)

  • DOI: https://doi.org/10.1007/978-1-4612-4112-6

  • Publisher: Birkhäuser Boston, MA

  • eBook Packages: Springer Book Archive

  • Copyright Information: Birkhäuser Boston 1996

  • Hardcover ISBN: 978-0-8176-3876-4Published: 28 August 1996

  • Softcover ISBN: 978-1-4612-8658-5Published: 06 January 2012

  • eBook ISBN: 978-1-4612-4112-6Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XIV, 420

  • Topics: Diabetes, Animal Models, Pharmacology/Toxicology

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