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Growth Hormone and the Heart endeavors to bring together knowledge that has been accumulated in the area of GH and the heart, from basic to clinical studies, by research groups working on this topic throughout the world. Lessons from different experimental models and from several human diseases (acromegaly, adult GH deficiency, heart failure) suggest to endocrinologists and cardiologists that GH may not only have a role in the physiology and pathophysiology of heart function, but that GH itself may have a place in the treatment of primary heart diseases (such as dilated cardiomyopathy) or of cardiac complications of hypopituitarism. Growth Hormone and the Heart will be a useful update of the research produced in the field of cardiovascular endocrinology. The Editors also hope that this book will serve as the primary step in the recognition of the wide physiological and clinical significance of GH and heart interactions.
List of Contributors. Preface; R. Vigneri. Introduction; A. Giustina, F. Manelli. Growth Hormone and the Heart: 1. The cellular and molecular basis for growth hormone action on the heart; A. Cittadini, P.S. Douglas. 2. Physiological effects of growth hormone on the heart; G. Lombardi, A. Colao. 3. The heart and the growth hormone deficiency syndrome; M.L. Vance. 4. Growth hormone replacement and cardiac function in the GHD adults; L. Thuesen, J.S. Christiansen. 5. The heart in acromegaly; M. Losa, K. Von Werder. 6. Impact of growth hormone-lowering treatments on heart function in acromegaly; P. Chanson. 7. Growth hormone secretion in congestive heart failure; F. Manelli, et al. 8. The growth hormone axis in cachectic patients with chronic heart failure: evidence for acquired growth hormone resistance; S.D. Anker, et al. 9. Growth hormone treatment in experimental heart failure; J. Isgaard, B.A. Bengtsson. 10. Acute growth hormone effects in human subjects with heart failure; F. Manelli, et al. 11. Effect of chronic growth hormone treatment in heart failure; M. Volterrani, et al. 12. Does the growth factor approach have a future in the treatment of human heart failure? L. Saccá, et al. 13. Exercise and growth hormone secretion; J.D. Veldhuis, A. Weltman. 14. Growth hormone and skeletal muscle function; E.C. Degli Uberti, et al. 15. Growth hormone and nutritional status; M. Scacchi, et al. 16. Effects of growth hormone on sodium homeostasis;G.Y.W. Kam, et al. 17. Growth hormone and exercise performance; W.B. Wehrenberg, et al. 18. IGF-1 and the heart; M.Y. Donath, J. Zapf. 19. Growth hormone-releasing peptides and the heart; V. Locatelli, et al. Index.