Helicobacter pylori Infection and Immunity

1. Front Matter

   Pages i-xxix

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2. The Bacteriology of Helicobacter pylori

   • Paul S. Hoffman

   Pages 1-17

3. Diagnosis of Helicobacter pylori Infection

   • Francis Mégraud, Tamara Matysiak

   Pages 19-34

4. Helicobacter pylori Infection and Gastric Cancer

   • Pelayo Correa

   Pages 35-47

5. Risk Factors and Peptic Ulcer Pathology

   • Benjamin D. Gold, Philip M. Sherman

   Pages 49-70

6. Helicobacter pylori Eradication Therapy

   • Jia-Qing Huang, Richard H. Hunt

   Pages 71-85

7. Mechanism of Antibiotic Resistance in Helicobacter pylori

   • Ge Wang, Diane E. Taylor

   Pages 87-104

8. Anti-Helicobacter pylori Activity of Natural Substances

   • Yoshimasa Yamamoto

   Pages 105-119

9. Adherence of Helicobacter pylori to Gastric Cell

   • Shigeru Kamiya, Hiroyuki Yamaguchi

   Pages 121-134

10. Helicobacter pylori, Molecular Mimicry and Autoimmunity

    • Ben J. Appelmelk, Gerhard Faller, Christina M.J.E. Vandenbroucke-Grauls

    Pages 135-152

11. Apoptosis and the Pathogenesis of Helicobacter pylori—Related Disease

    • Emilia Mia Sordillo, Steven F. Moss

    Pages 153-171

12. Toxins, Travels and Tropisms: H. pylori and Host Cells

    • Nina R. Salama, Stanley Falkow, Karen M. Ottemann

    Pages 173-201

13. Role of Cytokines in Helicobacter pylori Infection

    • Jean E. Grabtree

    Pages 203-213

14. Animal Models of Helicobacter pylori Infection

    • Ingrid L. Bergin, James G. Fox

    Pages 215-251

15. Mongolian Gerbils Model

    • Takashi Shimoyama, Takashi Sakagami, Noriyasu Yamamoto, Yukio Sawada, Yoshihiro Fukuda, Noritoshi Tanida et al.

    Pages 253-261

16. Vaccine Development

    • Thomas G. Blanchard, Steven J. Czinn

    Pages 263-279

17. Back Matter

    Pages 281-286

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The discovery and concept that Helicobacter pylori is associated with gastric disease including gastric cancer which is one of the most common and frequently lethal forms of malignancy, heralded a new and rapidly expanding field recognizing the emergence of many new pathogens and disease syndromes in clinical medicine, as well as basic infectious disease research. There is now an extensive and widely known literature of how H. pylori is involved in a wide variety of disease syn­ dromes. As summarized in the introductory chapter of this volume, many major advances have been made in diagnosis, both serologic and endoscopic in time of the involvement of this organism in patients with upper GI ailments as well as its presence in those who are not clinically ill. The Introduction describes the rapid development of understanding the role of this organism in disease. The basic bacteriology of H. pylori is then described in the second chapter. Diagnostic tests for detecting H. pylori infection is then highlighted, as well as the role of such infection in gastric cancer. Current knowledge concerning risk factors and peptic ulcer pathology associated with H. pylori is then described. Newer information concerning therapy of H. pylori infection and colonization is described in a subsequent chapter as well as one concerning the effects of anti­ biotics on H. pylori infection. The extensive literature on natural substances with anti-H.

• antibiotics
• autoimmunity
• bacteriology
• infection
• infectious
• vaccine
• infectious diseases

• University of South Florida College of Medicine, Tampa, USA

  Yoshimasa Yamamoto, Herman Friedman

• Dalhousie University, Halifax, Nova Scotia, Canada

  Paul S. Hoffman

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