Basic and Clinical Aspects of Growth Hormone

1. Front Matter

   Pages i-xi

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2. Processing of Growth Hormone

   1. Front Matter

      Pages 1-1

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   2. Growth Hormone Gene Expression: Hormonal Regulation and Tissue-Specific Expression

      • Norman L. Eberhardt, Peter A. Cattini, Linda N. Peritz, John D. Baxter, Randy Isaacs, Daniel F. Catanzaro et al.

      Pages 3-12

   3. Heterogeneity of Growth Hormone

      • Gerhard Baumann

      Pages 13-31

   4. Some Aspects on the Biochemistry of Growth Hormone

      • Choh Hao Li

      Pages 33-42

   5. Multiple Forms of Growth Hormone

      • U. J. Lewis, R. N. P. Singh, L. J. Lewis, N. Abadi

      Pages 43-55

   6. Genetic Defects in Processing Growth Hormone

      • John A. Phillips III

      Pages 57-67

   7. Summary of Session I Processing of Growth Hormone

      • John A. Phillips III

      Pages 69-70

3. Neuroendocrine Regulation of Growth Hormone Secretion

   1. Front Matter

      Pages 71-71

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   2. Interactions Between Growth Hormone Releasing Hormone, Somatostatin and Galanin in the Control of Growth Hormone Secretion

      • Steven M. Gabriel, Patricia E. Marshall, Joseph B. Martin

      Pages 73-82

   3. The Role of Neurotransmitters in Growth Hormone Secretion

      • Eugenio E. Muller, Vittorio Locatelli, Silvano G. Cella, Sandro Loche, Ezio Ghigo, Daniela Cocchi et al.

      Pages 83-94

   4. Acromegaly

      • Hiroo Imura, Yuzuru Kato, Naoki Hattori

      Pages 95-103

   5. Summary of Session II Neuroendocrine Regulation of Growth Hormone Secretion

      • John S. Parks

      Pages 105-106

4. Assessment of Growth Hormone Secretion in Children

   1. Front Matter

      Pages 107-107

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   2. Dynamics of GH Secretion in Children

      • Kerstin Albertsson-Wikland, Sten Rosberg

      Pages 109-118

   3. Growth Hormone Neurosecretory Dysfunction: Update

      • Barry B. Bercu

      Pages 119-141

   4. Growth Hormone Secretion and Growth in Central Nervous System Irradiated Children

      • R. Rappaport, M. Fontoura, R. Brauner

      Pages 143-155

   5. Age and Sex-Related Neurosecretion of Growth Hormone

      • W. S. Evans, K. Y. Ho, A. C. S. Faria, R. J. Krieg Jr., P. M. Martha Jr., D. A. Leong et al.

      Pages 157-172

   6. Chronobiology of Growth Hormone Secretion

      • Hans-Jurgen Quabbe

      Pages 173-183

   7. Summary of Session III Assessment of Growth Hormone Secretion in Children

      • Milo Zachmann

      Pages 185-186

In this era of proliferation of synthetic growth hormone in the marketplace, there is a parallel and accentuated interest in growth hormone in the scientific arena. Because many more people can be treated with available growth hormone, clinicians must be prepared to answer hard questions regarding appropriate therapeutic usage and their decisions should be based on substantiated research in growth hormone. In June 1987, an international group of basic and clinical inves­ tigators gathered in Tampa, Florida, to address these issues and to further explore the very nature of growth hormone. The presentations contained within this book bring together their most current and vital research related to growth hormone. Section I deals with an examination of the molecular and biochemical events which define the growth hormone process. In Section II the neuroregulation of growth hormone secretion is highlighted from contrasting perspectives. The third section emphasizes and defines methods of diagnosis of growth hormone deficiency states. Section IV reviews the physiology, biochemistry and molecular actions of growth hormone and somatomedin. Section V represents an assessment of growth hormone treatment for various disorders, and the sixth section expands current uses of growth hormone therapy as it evolves into the next decade. The symposium upon which this book is based proved to be a dynamic blending of scholarly interaction between basic and clinical scientists. I am indebted to the participants whose worthy contributions are reflected in these pages.

• assessment
• diagnosis
• glucocorticoid
• growth factor
• growth hormone receptors
• hormone receptors
• insulin
• insulin-like
• physiology
• therapy

• University of South Florida, Tampa, USA

  Barry B. Bercu

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