Smith, Lee B., Mitchell, Rod T., McEwan, PhD, Iain J.
2013, XI, 73 p. 12 illus., 10 illus. in color.
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Summarizes the current field by key contributors, still active in this area of research
Includes information on the role of testosterone in females
Has information on the new roles emerging for testosterone action in other body systems
This volume provides a brief résumé of the history of testosterone research, from the early pioneers through to the most recent advances in the field. We discover how steroid hormones were first identified and how testosterone was shown to be essential for male development. Moving forward we explore how and where testosterone is produced, and how the body controls testosterone production. We then investigate the impact testosterone has on different body systems both during their development and function, and how perturbation of testosterone action is associated with disease. We complete our story with an exploration of the emerging roles of testosterone in clinical therapy, and the future potential for manipulation of the testosterone signaling system for human health benefit.
Chapter 1. History of Masculinization.- Chapter 2. Recent Understanding of Masculinization.- Chapter 3. Where Does Testosterone Come From and how does it act?.- Chapter 4. Androgen Receptor Signalling in Testes.- Chapter 5. Androgen Signalling in Other Body Systems.- Chapter 6. Manipulating Androgens for Therapy.- Chapter 7. Future perspectives.