Cell Death in Reproductive Physiology

1. Front Matter

   Pages i-xix

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2. Dissecting the Functions, Mechanisms, and Genes of Physiological Cell Death in Reproductive Tissues: An Overview

   • Jonathan L. Tilly, Kim I. Tilly

   Pages 1-7

3. C. elegans as a Model system for Germ Cell Death

   • Tina L. Gumienny, Michael O. Hengartner

   Pages 8-18

4. Stem Cell Factor Regulation of Apoptosis in Mouse Primordial Germ Cells

   • Maurizio Pesce, Maria Grazia Farrace, Alessandra Amendola, Mauro Piacentini, Massimo De Felici

   Pages 19-31

5. Developmental Consequences of Programmed Cell Death in Human Preimplantation Embryos

   • Andrea Jurisicova, Sussanah L. Varmuza, Robert F. Casper

   Pages 32-47

6. Control of Apoptosis in the Uterus during Decidualization

   • Bruce C. Moulton, Kamil C. Akcali, Thomas F. Ogle, Thomas L. Brown, Joan Motz, Sohaib A. Khan

   Pages 48-66

7. Molecular Mechanisms of Müllerian Inhibiting Substance-Mediated Apoptosis

   • Patricia K. Donahoe, Tongwen Wang

   Pages 67-73

8. A Program of Cell Death and Extracellular Matrix Degradation in Fetal Membranes Prior to Labor

   • Hanqin Lei, Violetta Delgado, Emma E. Furth, Laurie G. Paavola, Felipe Vadillo-Ortega, Jerome F. Strauss III

   Pages 74-77

9. Apoptosis-Susceptible Versus-Resistant Granulosa Cells from Hen Ovarian Follicles

   • Alan L. Johnson

   Pages 78-92

10. Ultrastructural Aspects of cAMP and p53-Mediated Apoptosis in Normal and ras-Transformed Granulosa Cells

    • Abraham Amsterdam, Maren Breckwoldt, Ada Dantes, Selvaraj Natarajagounder, Dorit Aharoni

    Pages 93-102

11. Regulation of Apoptosis Versus Mitosis in Immature Granulosa Cells

    • David W. Schomberg, Jonathan L. Tilly

    Pages 103-110

12. Cell-to-Cell Contact and the Role of Cadherins Cell Survival

    • John J. Peluso

    Pages 111-124

13. The Central Role of Basement Membrane in Functional Differentiation, Apoptosis, and Cancer

    • Mina J. Bissell

    Pages 125-140

14. Reactive Oxygen Species and Antioxidants in Luteal Cell Demise

    • Harold R. Behrman, Raymond F. Aten, Pinar Kodaman, Tony G. Zreik, Paolo Rinaudo

    Pages 141-160

15. Potential Regulators of Physiological Cell Death in the Corpus Luteum

    • Bo R. Rueda, Debora L. Hamernik, Patricia B. Hoyer, Jonathan L. Tilly

    Pages 161-181

16. ICER and the Nuclear Response to cAMP

    • Carlos A. Molina

    Pages 182-193

17. Clinical Ramifications of Apoptosis in the Human Testis

    • Leo Dunkel, Krista Erkkilä, Seppo Taskinen, Sakari Wikström, Håkan Billig, Jonathan L. Tilly

    Pages 194-207

18. Apoptosis and Tumor Invasion in Hormone-Dependent Cancers

    • Martin Tenniswood, Sean Guenette, Colm Morrissey, Jacintha O’Sullivan, Zhengqi Wang, Ping Zhan et al.

    Pages 208-229

19. Cell Volume Regulation and the Movement of Ions during Apoptosis

    • Carl D. Bortner, John A. Cidlowski

    Pages 230-248

20. Apoptosis in the Ovary: The Role of DNase I

    • David L. Boone, Benjamin K. Tsang

    Pages 249-271

The regulation of cell death in various reproductive tissues, as in other ma­ jor organ systems of the body, has become a focal point of research activity in many laboratories over the past few years. As such, the need for a "for­ mal" meeting to highlight recent work in this field, as well as to integrate knowledge from other sources (such as investigators working on cell death in cancer and immune function) in the broad context of identifying con­ served pathways that coordinate life-and-death decisions in diverse cell types, became apparent. Therefore, the goals of the Scientific Committee of the International Symposium on Cell Death in Reproductive Physiology, spon­ sored by Serono Symposia USA, were already predetermined by this need. Simply stated, we sought to bring together for the first time a select cohort of reproductive biologists and cell death researchers, many but not all cho­ sen based on their pioneering efforts in elucidating the fundamental aspects of apoptosis in reproductive and nonreproductive tissues, as a means to re­ view the current status of the field, foster new ideas, and promote scientific collaborations. In the ensuing chapters of this book, summaries of work dis­ cussed at the meeting are presented to emphasize both the diversity and the similarities in the occurrence and regulation of apoptosis in tissues of the male and female reproductive systems.

• Embryo
• Uterus
• hormones
• physiology
• regulation
• tissue

• Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, USA

  Jonathan L. Tilly

• Center for Research on Reproduction and Women’s Health, University of Pennsylvania School of Medicine, Philadelphia, USA

  Jerome F. Strauss

• W. Alton Jones Cell Science Center, Lake Placid, USA

  Martin Tenniswood

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