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Oxidative Stress in Aging

From Model Systems to Human Diseases

  • Book
  • © 2008

Overview

Editors:
  1. Satomi Miwa

    1. Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK

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  2. Kenneth B. Beckman

    1. Functional Genomics Core, Children's Hospital Oakland Research Institute, Oakland, USA

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  3. Florian L. Muller

    1. Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, USA

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  • State-of-the-art overview of the free radical theory of aging and oxidative biochemistry
  • Evaluates the role of oxidative stress in the aging process in different model organisms
  • Discusses connection between free radicals, various diseases, and age-related pathological conditions
  • Reviews major interventions trials of antioxidant supplements in age-related diseases
  • Includes supplementary material: sn.pub/extras

Part of the book series: Aging Medicine (AGME)

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Table of contents (17 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Introduction

    1. Introduction

      • Satomi Miwa, Florian L. Muller, Kenneth B. Beckman
      Pages 3-10

    2. The Basics of Oxidative Biochemistry

      • Satomi Miwa, Florian L. Muller, Kenneth B. Beckman
      Pages 11-35

  3. The Role of Oxidative Stress in Aging

    1. Different Model Systems

      1. Retrograde Response, Oxidative Stress, and Cellular Senescence
        • João F. Passos, Thomas von Zglinicki
        Pages 39-52
      2. Reactive Oxygen Species in Molecular Pathways Controlling Aging in the Filamentous Fungus <i>Podospora anserina</i>
        • Heinz D. Osiewacz, Christian Q. Scheckhuber
        Pages 53-65
      3. <b>Oxidative Stress and Aging in the Budding Yeast</b> <b><i>Saccharomyces cerevisiae</i></b>
        • Stavros Gonidakis, Valter D. Longo
        Pages 67-79
      4. <b>Oxidative Stress and Aging in the Nematode</b> <b><i>Caenorhabditis elegans</i></b>
        • David Gems, Ryan Doonan
        Pages 81-110
      5. <b>Roles of Oxidative Stress in the Aging Process of</b> <b><i>Drosophila melanogaster</i></b>
        • Robin J. Mockett, Rajindar S. Sohal, William C. Orr
        Pages 111-128
      6. Does Oxidative Stress Limit Mouse Life Span?
        • Florian L. Muller
        Pages 129-146

    2. The Comparative Approach

      1. Mitochondrial Free Radical Production and Caloric Restriction: Implications in Vertebrate Longevity and Aging
        • Mónica López-Torres, Gustavo Barja
        Pages 149-162

  4. Oxidative Stress in Human Aging and Diseases

    1. Deregulation of Mitochondrial Function: A Potential Common Theme for Cardiovascular Disease Development

      • Scott W. Ballinger
      Pages 165-189

    2. Oxidative Stress in Type 2 Diabetes Mellitus

      • Muhammad A. Abdul-Ghani, Ralph A. DeFronzo
      Pages 191-211

    3. DNA Oxidative Damage and Cancer

      • Jeffrey A. Stuart, Melissa M. Page
      Pages 213-228

    4. Oxidative Stress in Hypertension

      • Sean P. Didion, Sophocles Chrissobolis, Frank M. Faraci
      Pages 229-251

    5. Aging and Cardiac Ischemia—Mitochondria and Free Radical Considerations

      • Paul S. Brookes, David L. Hoffman
      Pages 253-267

    6. Role of the Antioxidant Network in the Prevention of Age-Related Diseases

      • Mauro Serafini
      Pages 269-289

  5. Future

    1. Reactive Oxygen Species as Signaling Molecules

      • Ilsa I. Rovira, Toren Finkel
      Pages 293-307

    2. Summary and Outlook

      • Satomi Miwa, Florian L. Muller, Kenneth B. Beckman
      Pages 309-312

  6. Back Matter

    Pages 313-320
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Keywords

About this book

Oxidative Stress in Aging: From Model Systems to Human Diseases discusses the role of free radicals in aging in different animal models, as well as the relevance of free radicals on age-related diseases and pathological conditions in humans (following an introduction section of the basics and theory of free radicals). Human aging is a complex phenomenon - not everyone gets the same diseases and dies from the same cause. Accumulating reports implicate the connection between free radicals and various diseases and age-related pathological conditions. Although the causal relationships have not been established, it is necessary to discuss how free radicals are involved in each situation. In addition, the major interventions trials of antioxidant supplements in age-related disease, cancer and so forth are reviewed and discussed.

Editors and Affiliations

  • Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK

    Satomi Miwa

  • Functional Genomics Core, Children's Hospital Oakland Research Institute, Oakland, USA

    Kenneth B. Beckman

  • Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, USA

    Florian L. Muller

Bibliographic Information

  • Book Title: Oxidative Stress in Aging

  • Book Subtitle: From Model Systems to Human Diseases

  • Editors: Satomi Miwa, Kenneth B. Beckman, Florian L. Muller

  • Series Title: Aging Medicine

  • DOI: https://doi.org/10.1007/978-1-59745-420-9

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Humana Press 2008

  • Hardcover ISBN: 978-1-58829-991-8Published: 30 May 2008

  • Softcover ISBN: 978-1-61737-870-6Published: 10 December 2010

  • eBook ISBN: 978-1-59745-420-9Published: 17 June 2008

  • Edition Number: 1

  • Number of Pages: VIII, 320

  • Number of Illustrations: 27 b/w illustrations, 1 illustrations in colour

  • Topics: Geriatrics/Gerontology, Internal Medicine, Cell Biology

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