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Mosaicism in Human Skin

Understanding Nevi, Nevoid Skin Disorders, and Cutaneous Neoplasia

  • Book
  • © 2014

Overview

Authors:
  1. Rudolf Happle

    1. Department of Dermatology, Freiburg University Medical Center, Freiburg, Germany

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  • Comprehensive overview on mosaicism and mosaic patterns

  • Helps to understand the underlying molecular mechanisms of skin disorders

  • Concise, reader-friendly structured, lavishly illustrated

  • Written by a well-known expert of the field

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Introduction

    • Rudolf Happle
    Pages 1-2

  3. The Mechanisms of Cutaneous Mosaicism

    1. Front Matter

      Pages 3-3
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    2. Mosaicism as a Biological Concept

      • Rudolf Happle
      Pages 5-12

    3. Two Major Categories of Mosaicism

      • Rudolf Happle
      Pages 13-37

    4. Relationship Between Hypomorphic Alleles and Mosaicism of Lethal Mutations

      • Rudolf Happle
      Pages 39-42

  4. The Patterns of Cutaneous Mosaicism

    1. Front Matter

      Pages 43-43
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    2. Six Archetypical Patterns

      • Rudolf Happle
      Pages 45-61

    3. Less Well Defined or So Far Unclassifiable Patterns

      • Rudolf Happle
      Pages 63-65

  5. Mosaic Skin Disorders

    1. Front Matter

      Pages 67-67
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    2. Nevi

      • Rudolf Happle
      Pages 69-108

    3. Didymotic Skin Disorders

      • Rudolf Happle
      Pages 109-114

    4. Other Binary Genodermatoses, Including “Pseudodidymosis”

      • Rudolf Happle
      Pages 115-120

    5. Mosaic Manifestation of Autosomal Dominant Skin Disorders

      • Rudolf Happle
      Pages 121-175

    6. Revertant Mosaicism

      • Rudolf Happle
      Pages 177-181

    7. Nevoid Skin Disorders

      • Rudolf Happle
      Pages 183-219

    8. A Note on Neoplastic Skin Lesions

      • Rudolf Happle
      Pages 221-222

  6. Back Matter

    Pages 223-229
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Keywords

About this book

Mosaicism is a powerful biologic concept, originally developed from studying plants and animals. All cutaneous neoplasms, both benign and malignant, reflect mosaicism, which is the necessary basis to explain numerous human skin disorders. For example, various mosaic patterns visualize the embryonic development of human skin and X-linked skin disorders explain why women live longer than men, and so on. This book presents, for the first time, a comprehensive overview on the strikingly manifold patterns and peculiarities of mosaic skin disorders. This reader-friendly structured and straightforward publication will help the dermatologist to understand the underlying molecular mechanisms of skin disorders in order to further improve the treatment outcome.

Authors and Affiliations

  • Department of Dermatology, Freiburg University Medical Center, Freiburg, Germany

    Rudolf Happle

Bibliographic Information

  • Book Title: Mosaicism in Human Skin

  • Book Subtitle: Understanding Nevi, Nevoid Skin Disorders, and Cutaneous Neoplasia

  • Authors: Rudolf Happle

  • DOI: https://doi.org/10.1007/978-3-642-38765-4

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2014

  • Softcover ISBN: 978-3-662-50205-1Published: 23 August 2016

  • eBook ISBN: 978-3-642-38765-4Published: 26 November 2013

  • Edition Number: 1

  • Number of Pages: XIII, 229

  • Number of Illustrations: 24 b/w illustrations, 208 illustrations in colour

  • Topics: Dermatology, Pediatrics, Human Genetics, Neurology, Ophthalmology

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