Aging Hair

1. Front Matter

   Pages i-xv

   PDF

2. Gerontobiology of the Hair Follicle

   • Desmond J. Tobin

   Pages 1-8

3. Molecular Basis of Androgenetic Alopecia

   • Valerie Anne Randall

   Pages 9-24

4. Inflammatory Phenomena and Fibrosis in Androgenetic Alopecia

   • Ralph M. Trüeb

   Pages 25-32

5. Post-Menopausal Frontal Fibrosing Alopecia

   • Steven Kossard

   Pages 33-39

6. Female Pattern Hair Loss

   • M. Javed Mohungoo, Andrew G. Messenger

   Pages 41-48

7. Hair Growth Parameters in Pre- and Postmenopausal Women

   • Paradi Mirmirani, Fangyi Luo, Scott R. Youngquist, Brian K. Fisher, James Li, John Oblong et al.

   Pages 49-60

8. Comparative Histopathology of Androgenetic Alopecia, Diffuse Alopecia, and Senescent Alopecia

   • David A. Whiting

   Pages 61-65

9. Comparative Gene Expression Profiling of Senescent and Androgenetic Alopecia Using Microarray Analysis

   • Paradi Mirmirani, Pratima Karnik

   Pages 67-76

10. The Aging Hair Pigmentary Unit

    • Desmond J. Tobin

    Pages 77-89

11. Oxidative Stress Associated Melanocyte-Loss and Hair Growth Capacity in the Aging Hair Follicle: A Model for Tissue-Specific Aging

    • Eva M. J. Peters

    Pages 91-100

12. Human Hair Follicle Melanocytes as a Proxy Cell Type in Neurodegeneration Research

    • Nikolaos Papageorgiou, Elisabeth Carpenter, Desmond J. Tobin

    Pages 101-111

13. Effect of UV Radiation on Scalp and Hair Growth

    • Claudine Piérard-Franchimont, Pascale Quatresooz, Gérald E. Piérard

    Pages 113-121

14. Hair Photoaging

    • Won-Soo Lee

    Pages 123-133

15. Effect of Tobacco Smoking on Hair

    • Ralph M. Trüeb

    Pages 135-139

16. Age-Related General Problems Affecting the Condition of Hair

    • Ralph M. Trüeb

    Pages 141-166

17. Aging of Scalp and Age-Related Disorders of Scalp

    • Desmond Gan, Rodney Sinclair

    Pages 167-182

18. Care of Aging Hair and Photoprotection

    • Zoe Diana Draelos

    Pages 183-191

19. Possibilities and Limitations for Reversal of Age-Related Hair Loss

    • Nina Otberg, Isabel Restrepo, Jerry Shapiro

    Pages 193-205

20. Possibilities and Limitations for Reversal of Age-Related Pigment Loss

    • Ralph M. Trüeb

    Pages 207-213

“Aged? But he does not appear aged, just look, his hair has remained young!” Marcel Proust, In Search of Lost Time (1913–27) The appearance of hair plays an important role in peoples’ overall physical appe- ance and self-perception. With today’s increasing life-expectation, the desire to look youthful plays a bigger role than ever. The hair care industry has become aware of this, and capable to deliver active products that are directed toward meeting this c- sumer demand. The discovery of pharmacological targets and the development of safe and effective drugs such as minoxidil and fnasteride also indicate strategies of the drug industry for maintenance of healthy and beautiful hair in the young and old. The study of hair aging focuses on two main streams of interest: On the one hand, the esthetic problem of aging hair and its management, in other words everything that happens outside the skin; on the other hand, the biological problem of aging hair, in terms of microscopic, biochemical, and molecular changes, in other words the “secret life” of the hair follicle in the depth of the skin. Hair aging comprises hair shaft aging, and aging of the hair follicle. The former involves weathering and photoaging of the hair shaft, while the latter manifests as decrease of melanocyte function (graying) and decrease in hair production (alopecia).

• UV radiation
• aging
• androgenetic alopecia
• care
• diagnosis
• diagnostics
• gene therapy
• hair wheathering
• histopathology
• prevention
• senescence
• senescent alopecia
• stress
• therapy
• treatment

• Dermatologische Klinik, Universitätsspital Zürich, Zürich, Switzerland

  Ralph M. Trüeb

• Centre for Skin Sciences, University of Bradford, Bradford, W. Yorks., United Kingdom

  Desmond J. Tobin

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