Liposome Dermatics

1. Front Matter

   Pages I-XIX

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2. General Considerations

   1. Front Matter

      Pages 1-1

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   2. Percutaneous Absorption and Conventional Penetration Enhancers

      • Helmut Loth

      Pages 3-10

   3. Lipid Flow Phenomena Between Liposomes, Lipoproteins and Cell Membranes; Applications in Drug Delivery

      • Gerrit L. Scherphof, Kazuo Maruyama, Marjan van Borssum Waalkes, Dick Hoekstra, Jan Damen, Stephen J. Kennel et al.

      Pages 11-19

   4. Basic Principles of Liposomes for Drug Use

      • Gary P. Martin, Andrew W. Lloyd

      Pages 20-26

3. Chemical Aspects

   1. Front Matter

      Pages 27-27

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   2. Phospholipids as Basic Ingredients

      • Alfred Blume

      Pages 29-37

   3. Liposome Dermatics: Chemical Aspects of the Skin Lipid Approach

      • Philip W. Wertz

      Pages 38-43

   4. Ceramides for Liposomes

      • Richard R. Schmidt

      Pages 44-56

   5. Liposome Phospholipids: Toxicological and Environmental Advantages

      • Michael J. Parnham

      Pages 57-65

4. Physico-chemical Aspects

   1. Front Matter

      Pages 67-67

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   2. Liposome Production: Historic Aspects

      • Y. Barenholz

      Pages 69-81

   3. Rationale for the Production and Dermal Application of Lipid Vesicles

      • G. Cevc

      Pages 82-90

   4. Liposome Production: The Ethanol Injection Technique and the Development of the First Approved Liposome Dermatic

      • Robert W. Kriftner

      Pages 91-100

   5. Liposome Production: The Sizing-Up Technology Starting from Mixed Micelles and the Scaling-Up Procedure for the Topical Glucocorticoid Betamethasone Dipropionate and Betamethasone

      • H. G. Weder

      Pages 101-109

   6. Properties and Characterization of Pre-Liposome Systems

      • Joachim Röding

      Pages 110-117

5. Technological Aspects

   1. Front Matter

      Pages 119-119

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   2. Changes in the Structure of the Human Stratum Corneum Induced by Liposomes

      • J. A. Bouwstra, H. E. J. Hofland, F. Spies, G. S. Gooris, H. E. Junginger

      Pages 121-136

   3. Monitoring in vivo Skin Hydration by Liposomes Using Infrared Spectroscopy in Conjunction with Tape Stripping

      • H. E. Boddé, L. A. R. M. Pechtold, M. T. A. Subnel, F. H. N. de Haan

      Pages 137-149

   4. Liposome Dermatics: Assessment of Long-Term Stability

      • Karl Thoma, Uwe E. Jocham

      Pages 150-166

In a multi-disciplinary approach the book deals with liposome dermatics fromthe chemist's, pharmacist's, biologist's as well as clinician's point of view. It features the production of liposomes, appropriate raw materials, encapsulation of active ingredients, possible incorporation into vehicles such as gels, assessment of stability, fate of liposomes and active ingredients exposed to animaland human skin both in vitro and in vivo, activity of topical liposome preparations in normal and inflamed skin in animal and man as well as efficacy in skin diseases in man. Other aspects covered comprise the ecological and juridic area. The scope being theoretical and practical at a time, the book provides a sound basis for future developments to meet the needs of patients suffering from so far recalcitrant skin diseases.

• Arzneimittelträger
• Dermatotherapy
• Drug Carrier System
• Hautkrankheiten
• Liposom
• Liposome
• Topical Drug
• Topische Arzneimittel
• tissue

• Dermatologische Klinik und Poliklinik, Ludwig-Maximilians-Universität München, München 2, Deutschland

  Otto Braun-Falco, Hans Christian Korting

• Department of Dermatology, University of California School of Medicine, San Francisco, USA

  Howard I. Maibach

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