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Therapeutic Uses of Botulinum Toxin

  • Book
  • © 2007

Overview

Editors:
  1. Grant Cooper

    1. Department of Physical Medicine and Rehabilitation New York Presbyterian Hospital, The University Hospital of Columbia and Cornell, New York

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  • Defines our current understanding of botulinum toxin and its method of action
  • Presents therapeutic uses across a variety of medical subspecialties and patient populations
  • Encourages responsible research into new and novel uses of botulinum toxin

Part of the book series: Musculoskeletal Medicine (MUM)

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-xiv
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  2. History and Mechanism of Action

    • Zinovy Meyler, Grant Cooper
    Pages 1-5

  3. Spasticity

    • Elise Weiss, David Lin
    Pages 7-18

  4. Radiation Fibrosis Syndrome

    • Michael D. Stubblefield
    Pages 19-38

  5. Low Back Pain

    • Rebecca Brown, Avniel Klein, Alex Visco, Joseph E. Herrera
    Pages 39-59

  6. Piriformis Syndrome

    • Loren M. Fishman, Alena Polesin, Steven Sampson
    Pages 61-74

  7. Plantar Fasciitis

    • Mary S. Babcock
    Pages 75-89

  8. Headache

    • Jerome S. Schwartz, Phillip Song, Andrew Blitzer
    Pages 91-108

  9. Spasmodic Dysphonia

    • Jerome S. Schwartz, Phillip Song, Andrew Blitzer
    Pages 109-121

  10. Sialorrhea and Frey’s Syndrome

    • Phillip Song, Jerome S. Schwartz, Andrew Blitzer
    Pages 123-135

  11. Cosmetic Applications

    • Tara D. Miller, Isaac M. Neuhaus
    Pages 137-151

  12. Hyperhydrosis

    • Joely Kaufman, Leslie Baumann
    Pages 153-166

  13. Urological Applications

    • David E. Rapp, Gregory T. Bales
    Pages 167-193

  14. Gastrointestinal Applications

    • Shayan Irani, Frank K. Friedenberg
    Pages 195-207

  15. Blepharospasm

    • Amir Cohen, Marc J. Spirn, David Khoramian, C. Robert Bernardino
    Pages 209-221

  16. Economics, Immunity, and Future Directions

    • Victoria Chan Harrison, David Lin
    Pages 223-228

  17. Back Matter

    Pages 229-238
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Keywords

About this book

Justinius Kerner, a German medical officer and poet, was the first to realize that botulinum toxin potentially might be useful for therapeutic purposes. Kerner made this observation in 1822, but he did not call the toxin “botulinum toxin. ” Instead, Kerner called it the substance in “wirkenden stoffes,” which translates to “bad sausages. ” Kerner realized that there was a “fat poison” or “fatty acid” within sausages that produced the toxic effects that we now know as botulism. Nearly a century would pass before the bacterium producing the toxin would be isolated and the toxin ultimately renamed “botulinum toxin. ” As farsighted as Kerner was, it is doubtful that even he could have predicted just how much potential therapeutic punch was packed within his wirkenden stoffes. It was not until 1978, more than a century and a half after Kerner’s prediction, that Dr. Allan Scott received Food and Drug Administration approval to test botulinum toxin type A in human volunteers. We do not yet have a comprehensive understanding of precisely how botulinum toxin works in the human body or how our bodies fully respond to the toxin. We do know that it temporarily paralyzes muscle by inhibiting the release of acetylcholine, and it also appears to inhibit the release of other neurotransmitters.

Reviews

From the reviews:

"This book presents many of the clinical uses of the relatively new drug, botulinum toxin. … the book attempts to cover nearly all uses of the medication known to the assorted authors, including potential treatments for which there is little peer-reviewed literature. The purpose is to provide an overview of this medication, and present clinical scenarios in which the drug might be an appropriate choice. … The target audience should be clinicians (physicians and therapists) ... ." (Ross Bogey, Doody’s Review Service, January, 2008)

Editors and Affiliations

  • Department of Physical Medicine and Rehabilitation New York Presbyterian Hospital, The University Hospital of Columbia and Cornell, New York

    Grant Cooper

Bibliographic Information

  • Book Title: Therapeutic Uses of Botulinum Toxin

  • Editors: Grant Cooper

  • Series Title: Musculoskeletal Medicine

  • DOI: https://doi.org/10.1007/978-1-59745-247-2

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Humana Press 2007

  • Hardcover ISBN: 978-1-58829-914-7Published: 13 June 2007

  • Softcover ISBN: 978-1-61737-842-3Published: 08 September 2011

  • eBook ISBN: 978-1-59745-247-2Published: 05 October 2007

  • Series ISSN: 2626-8663

  • Series E-ISSN: 2626-8671

  • Edition Number: 1

  • Number of Pages: XIV, 238

  • Topics: Dermatology, Orthopedics, Rehabilitation Medicine, Pharmacology/Toxicology

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