Immune Response in the Critically Ill

1. Front Matter

   Pages I-XIV

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2. The Four Ds of the Danger Model: Distress, Damage, Destruction, and Death

   • P. Matzinger

   Pages 1-11

3. The Immune Response in Critical Illness: Excessive, Inadequate or Dysregulated

   • J. L. Vincent

   Pages 12-21

4. Genomics of the Sepsis Syndrome

   • S. J. H. van Deventer, P. Stokkers

   Pages 22-36

5. The Pro-Inflammatory Cytokine Cascade

   • J.-M. Cavaillon, M. Adib-Conquy

   Pages 37-66

6. Inhibitory Cytokines

   • T. Calandra, D. Heumann

   Pages 67-83

7. Interleukin-1β and Interleukin-18: Two Cytokine Precursors for Interleukin-1 β Converting Enzyme (Caspase-1)

   • C. A. Dinarello

   Pages 84-96

8. Bacterial Toxins Induce Selective Cytokine Patterns In Vivo and In Vitro

   • J. Andersson, U. Andersson

   Pages 97-115

9. The Acute Phase Response and Enhancing Resistance to Bacterial Infection

   • M. Noursadeghi, J. Cohen

   Pages 116-139

10. Cytokines as Mediators of Lung Innate Immunity

    • T. J. Standiford, B. Merhad, W. C. Tsai

    Pages 140-154

11. Fetuin Opsonizes Macrophage-Deactivating Cations

    • H. Wang, K. J. Tracey

    Pages 155-163

12. LPS Receptors

    • E. Lien, H. Heine, D. T. Golenbock

    Pages 164-172

13. Regulation of Cellular Responses to Bacterial Endotoxin

    • R. J. Ulevitch

    Pages 173-181

14. The Role of Nitric Oxide in the Initiation of Inflammation in Shock

    • R. T. Villavicencio, T. R. Billiar

    Pages 182-189

15. Regulation of Neutrophil Activation in Acute Lung Injury and SIRS

    • J. Kruger, Q. Dong, G. Downey

    Pages 190-209

16. Neutrophils and Acute Lung Injury

    • C. Haslett, S. Donnelly, N. Hirani

    Pages 210-225

17. Lymphocyte Activation, Anergy, and Apoptosis in Polymicrobial Sepsis

    • A. Ayala, C. S. Chung, G. Y. Song

    Pages 226-246

18. Trauma Mediators Favor Differentiation of Monocytes to Macrophage Rather Than to Dendritic Cells

    • C. L. Miller-Graziano, A. K. De, K. Kodys

    Pages 247-263

19. Programmed Cell Death (Apoptosis) and the Immunologic Derangements of Critical Illness

    • R. Taneja, L. Yue, J. C. Marshall

    Pages 264-279

20. The Interaction Between the Coagulation System and the Systemic Inflammatory Mediators

    • S. M. Opal

    Pages 280-291

This book brings together basic scientists or clinicians from a variety of different backgrounds - immunology, infectious diseases or critical care - who share a common interest in understanding the changes that occur in immune responses in sepsis. It provides an up-to-date and unrivalled synthesis of current research in this rapidly developing field.

• Immunologie
• Sepsis
• Trauma
• apoptosis
• bacteria
• care
• critical care
• cytokine
• immunology
• infection
• infectious disease
• innate immunity
• programmed cell death
• resistance
• shock

• Department of Surgery Interdepartmental Division of Critical Care Medicine, Toronto General Hospital University of Toronto, Toronto, Canada

  John C. Marshall

• Department of Infectious Diseases & Microbiology Division of Investigative Science, Imperial College School of Medicine Hammersmith Hospital, London, UK

  Jonathan Cohen

Policies and ethics