Mechanisms of Sepsis-Induced Organ Dysfunction and Recovery

1. Front Matter

   Pages I-XIV

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2. Setting the Scene

   1. Setting the Scene

      • J. L. Vincent

      Pages 1-14

3. The Inflammatory Response

   1. Front Matter

      Pages 15-15

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   2. Genetics and Severe Sepsis

      • J. Texereau, V. Lemiale, J. -P. Mira

      Pages 17-33

   3. Cell Signaling Pathways of the Innate Immune System During Acute Inflammation

      • S. M. Opal, P. A. Cristofaro

      Pages 35-53

   4. Early-Onset Pro-inflammatory Cytokines

      • C. Kaech, T. Calandra

      Pages 55-66

   5. The Significance of HMGB1, a Late-Acting Pro-inflammatory Cytokine

      • E. Abraham

      Pages 67-75

   6. Nitric Oxide

      • J. Carré, M. Singer, S. Moncada

      Pages 77-95

   7. Involvement of Reactive Oxygen and Nitrogen Species in the Pathogenesis of Acute Lung Injury

      • S. Matalon, I. C. Davis, J. D. Lang Jr

      Pages 97-111

   8. Heat Shock Proteins in Inflammation

      • Z. Bromberg, Y. G. Weiss, C. S. Deutschman

      Pages 113-121

   9. Fibrosis in the Acute Respiratory Distress Syndrome

      • D. C. J. Howell, R. C. Chambers, G. J. Laurent

      Pages 123-135

   10. Resolution of Inflammation

       • G. Bellingan

       Pages 137-157

4. The Cellular Immune Respone

   1. Front Matter

      Pages 159-159

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   2. Compartmentalized Activation of Immune Cells During Sepsis and Organ Dysfunction

      • J. -M. Cavaillon, M. Adib-Conquy

      Pages 161-182

   3. The Neutrophil in the Pathogenesis of Multiple Organ Dysfunction Syndrome

      • Z. Malam, J. C. Marshall

      Pages 183-201

   4. The Role of the Macrophage

      • J. Pugin

      Pages 203-210

   5. The Role of the Endothelium

      • W. C. Aird

      Pages 211-227

   6. Differential Effects of Pro-Inflammatory Mediators on Alveolar Epithelial Barrier Function

      • M. A. Matthay, J. -W. Lee

      Pages 229-235

5. Mechanisms and Pathways of Dysfunction

   1. Front Matter

      Pages 237-237

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   2. Macrocirculatory Disturbances

      • D. De Backer

      Pages 239-247

There have been tremendous advances in understanding the cellular mechanisms involved in sepsis and contributing to the development of multiple organ dysfunction and mortality in this setting. The chapters in this book provide up-to-date insights into important pathways that are initiated by sepsis.

• Acute Lung Injury
• Criticall Illness
• Sepsis
• central nervous system
• immune system
• inflammation
• mortality
• muscle
• shock

• Health Sciences Center, Division Pulmonary & Critical Care Medicine, University of Colorado, Denver, USA

  Edward Abraham

• Bloomsbury Institute of Intensive Care, Division Medicine, University College Hospital, London, UK

  Mervyn Singer

Policies and ethics