Advances in Vascular Medicine

1. Front Matter

   Pages i-xviii

   PDF

2. Genetics and Gene Therapy

   1. Front Matter

      Pages 1-2

      PDF

   2. Oligonucleotide Therapeutics to Treat Dyslipoproteinemia and Atherosclerosis

      • Ioannis Papaioannou, James S. Owen

      Pages 5-23

   3. Gene Delivery to Cardiovascular Tissue

      • Rachel Masson, Stuart A. Nicklin, Andrew H. Baker

      Pages 25-54

3. Animal Models to Study Vascular Disease

   1. Front Matter

      Pages 56-56

      PDF

   2. Animal Models of Scleroderma: From Cellular and Molecular Mechanisms to Novel Antifibrotic Strategies

      • Mirko Manetti, Elena Neumann, Oliver Distler, Ulf Müller-Ladner

      Pages 57-75

   3. Animal Models of Atherosclerosis

      • Christopher Jackson, Ulrike Benbow, Andrew Bond, Deborah Galley, Claire Schwartz

      Pages 77-91

   4. Animal Models of the Endothelin System

      • Karoline von Websky, Susi Heiden, Thiemo Pfab, Berthold Hocher

      Pages 93-101

4. Molecules and Mediators and Therapeutic Applications

   1. Front Matter

      Pages 104-104

      PDF

   2. Endothelin-1 and Systemic Sclerosis

      • Jeremy D. Pearson, Xu Shi-wen, Sarah L. Howat, Christopher P. Denton, David J. Abraham

      Pages 105-111

   3. The Role of the Homeodomain Transcription Factor Nkx2-5 in the Cardiovascular System

      • Markella Ponticos

      Pages 113-130

   4. Cell Therapy for Cardiovascular Disease

      • Jonathan R. Murrow, Saurabh S. Dhawan, Arshed A. Quyyumi

      Pages 131-151

   5. Tissue-Engineered Vascular Substitutes: New Models Toward Successful Small Diameter Grafts

      • Pedro D’Orléans-Juste, Dan Lacroix, Lucie Germain, François A. Auger

      Pages 153-174

   6. Role of Perivascular Adipose Tissue in Vascular Function

      • Maria S. Fernández-Alfonso, Marta Gil-Ortega, Beatriz Somoza

      Pages 175-186

   7. Endothelium: Dysfunction and Repair

      • Muhiddin A. Ozkor, Jonathan R. Murrow, Arshed A. Quyyumi

      Pages 187-210

5. Clinical Aspects of Vascular Biology

   1. Front Matter

      Pages 213-214

      PDF

   2. Chronic Thromboembolic Pulmonary Hypertension

      • Joanna Pepke-Zaba

      Pages 215-224

   3. Pathophysiology of Chronic Thromboembolic Pulmonary Hypertension (CTEPH)

      • Jay Suntharalingam, Nicholas W. Morrell

      Pages 225-231

   4. Surgical Management of Chronic Thromboembolic Pulmonary Hypertension (CTEPH)

      • David P. Jenkins

      Pages 233-246

   5. Imaging in Acute and Chronic Pulmonary Thromboembolic Disease

      • Charlotte Cash, Joanne Cleverley

      Pages 247-272

Understanding the many complex cellular and molecular mechanisms underlying human vascular diseases is essential in improving the treatment of this important and wide-ranging group of diseases that affect a large proportion of the world po- lation. This book is based on lectures presented at an International Vascular Biology Workshop held in London and chaired by Professor Dame Carol Black. The c- tents are complemented by some invited chapters, all written by world experts in areas of basic science and clinical medicine highly relevant to vascular biology and disease. We are particularly grateful to Professor Arshed Quyyumi, Professor of Medicine and Cardiology at Emory University, who with his research group and clinical colleagues, has provided a substantial contribution to this book. In common with our previous book – Vascular Complications in Human Disease: Mechanisms and Consequences published by Springer in 2008, our aim with this book is to highlight some of the established relationships between basic science and clinical medicine, and to outline new and exciting fields of research and practice in vascular biology and pathobiology. There are two sections: Basic Science of Vascular Biology and Clinical Aspects of Vascular Biology. In the first section, dealing with basic science, we have included three important growth areas: “Genetics and Gene Therapy” cover approaches to gene therapy and delivery systems, “Animal Models to Study Vascular Disease” with chapters on animal models of scleroderma, animal models of atherosclerosis, and finally on the endothelin system.

• Bypass
• cardiovascular
• cells
• endothelium
• hypertension
• pathophysiology
• physiology
• surgery
• tissue

From the reviews: “This collection presents focused discussions on the current understanding of endothelial function, atherosclerosis, pulmonary hypertension, systemic sclerosis, and chronic thromboembolic disease. … It is directed at a diverse audience of scientists and physicians who specialize in vascular disease. … provides clinical insight, which is useful for basic scientists and clinical researchers. It also offers vascular surgeons, cardiologists, rheumatologists, and vascular medicine physicians … . The high quality writing offers stimulating and relevant ideas to both investigators and clinicians.” (Judith L. Meadows, Doody’s Review Service, May, 2010)

• University College London, London, United Kingdom

  David Abraham, Michael Dashwood

• The Royal Free & Univ College Med School, London, United Kingdom

  Handler Clive, Gerry Coghlan

Professor David Abraham, Professor of Molecular Biology, University College London, London, UK.

Dr Clive Handler, Consultant in Pulmonary Hypertension, The Royal Free Hospital, and Honorary Senior Lecturer, The Royal Free and University College School of Medicine, London, UK.

Dr Michael Dashwood, Senior Lecturer in Biochemistry, University College London, London, UK.

Dr Gerry Coghlan, Consultant Cardiologist, The Royal Free Hospital, London, UK.

The Editors – two clinicians and two basic scientists, are all well known in their respective fields, and bring together this essential collaboration for this book dealing with scientific principles and clinical practice.

The Authors

These are world famous leaders and internationally acclaimed experts in the field.

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