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Provides a perspective on primary (heritable) electrical disease of the heart and sudden cardiac death in cardiology, neurology, nephrology, endocrinology
Emphasizes clinical and basic aspects of the physiology and pathophysiology in conjunction with new clinical findings and research discoveries
Thought-provoking and enlightening emphases on the latest research and clinical accomplishments
Structure of chapters: exposure to the experimental background of each electrical disease, syndrome, and ECG phenomenon stressing the relationship with clinical practice
The past decade has witnessed an explosion of knowledge and radical changes in our understanding of the molecular, ionic, genetic, and pharmacologic basis of electrical diseases of the heart. Electrical diseases of the heart are heritable arrhythmogenic clinical entities that may share common clinical and genetic features, yet may be distinctly different in their genesis, prognosis, and management. Notably, both congenital and acquired electrical diseases of the heart are receiving increased recognition as a result of important advances in genetic analysis.
Electrical Diseases of the Heart is a thorough clinical reference on the current status of cardiac electrophysiological disease,emphasizing common and diverse clinical features. The latest developments in the field of experimental and clinical cardiac electrophysiology, genetics, pharmacology, and interventional therapies of various clinical arrhythmogenic entities are featured and discussed in terms of recent advances in basic and clinical science. Residents, fellows, and physicians in cardiology and electrophysiology will gain valuable insight into cardiac electrophysiology and clinical electrocardiology by reading this book, including expert review of the genetic and epidemiologic considerations, diagnostic and therapeutic modalities of the newly discovered clinical syndromes, and electrocardiographic phenomena, and their correlation with the most recent advances in the basic science.
Basic Foundations of Normal and Abnormal Cardiac Electrical Activity.- The Past and Promise of Basic Cardiac Electrophysiology.- Basic Physiology of Ion Channel Function.- Developmental Aspects of the Electrophysiology of the Heart: Function Follows Form.- Anatomic and Histopathological Characteristics of the Conductive Tissues of the Heart.- Neural Regulation of the Heart in Health and Disease.- Mechanisms of Cardiac Arrhythmia.- Mechanisms of Action of Antiarrhythmic Drugs.- Mechanoelectrical Interactions and Their Role in Electrical Function of the Heart.- The Role of Cellular Sodium and Calcium Loading in Cardiac Energetics and Arrhythmogenesis: Contribution of the Late Sodium Current.- Sodium Ion Channelopathies.- L-type Calcium Channel Disease.- K+ Channelopathies (I Ks and I Kr).- Channelopathies of Cardiac Inwardly Rectifying Potassium Channels.- Calcium Release Channels (Ryanodine Receptors) and Arrhythmogenesis.- Caveolae and Arrhythmogenesis.- Senescence and Arrhythmogenesis.- Comparisons of Substrates Responsible for Atrial Versus Ventricular Fibrillation.- Single Nucleotide Polymorphisms in Health and Cardiac Disease.- Electrophysiological remodeling in Dilated Cardiomyopathy and Heart Failure.- Ventricular Electrical Remodeling in Compensated Cardiac Hypertrophy.- Physiological and Other Biological Pacemakers.- Clinical Rhythmology: Diagnostic Methods and Tools.- Diagnostic Electrocardiography.- Ambulatory Monitoring (Holter, Event Recorders, External, and Implantable Loop Recorders and Wireless Technology).- Signal Averaged Electrocardiogram.- Heart Rate Variability: Measurements and Risk Stratification.- Surface Mapping and Magnetoelectrocardiography.- Microvolt T Wave Alternans: Mechanisms and Implications for Prediction of Sudden Cardiac Death.- Invasive Electrophysiologic Testing: Role in Sudden Death Prediction.- Provocative Testing in Inherited Arrhythmias.- Novel Predictors of Sudden Cardiac Death.- Genetic Testing.- Heritable Cardiac Channelopathies, Primary Electrical Diseases, and Clinical Syndromes.- Celebrating the Challenge of Cardiac Arrhythmias.- Congenital Long QT Syndrome.- Brugada Syndrome: Clinical and Genetic Aspects.- Brugada Syndrome: Cellular Mechanisms and Approaches to Therapy.- Catecholaminergic Polymorphic Ventricular Tachycardia.- Andersen-Tawil and Timothy Syndromes.- Short QT Syndrome.- Progressive Cardiac Conduction Disease.- Familial Atrial Fibrillation and Standstill.- Idiopathic Ventricular Fibrillation.- Secondary Hereditary Electrical Diseases and Clinical Syndromes.- Cardiac Remodeling.- Arrhythmogenic Malignancies in Hypertrophic Cardiomyopathy.- Sudden Death in Dilated Cardiomyopathy and Skeletal Myopathies.- Ventricular Arrhythmias in Right Ventricular Dysplasia/Cardiomyopathy.- The Wolff-Parkinson-White Syndrome and the Risk of Sudden Death.- Iatrogenic (Drug-Induced) Cardiac Channelopathies and Sudden Cardiac Death.- Drug-Induced Enhanced Risk for Sudden Cardiac Death in Clinical Practice, Clinical Research, and Drug Development.- Pharmacogenomics in Drug Development and Clinical Research.- Mechanisms of Drug-Induced Cardiac Toxicity.- Acquired (Drug-Induced) Long QT Syndrome.- Acquired Form of Brugada Syndrome.- Treatment Modalities.- Treatment Modalities.- Clinical Role of Antiarrhythmic Drugs in the Prevention of Sudden Death.- Nonantiarrhythmic Drugs in Sudden Death Prevention.- The Implantable Cardioverter Defibrillator: Technical and Clinical Considerations.- Beyond Sudden Death Prevention: Minimizing Implantable Cardioverter Defibrillator Shocks and Morbidity and Optimizing Efficacy.- Pacing and Cardiac Resynchronization.- Device Therapy for Remote Patient Management.- Catheter Ablation of Ventricular Tachycardia and Fibrillation.- Surgical Treatment of Atrial Fibrillation.- Risk Stratification and Prevention of Sudden Cardiac Death in Acquired Clinical Conditions.- Screening for Risk of Sudden Cardiac Death.- Clinical Trials in Sudden Cardiac Death Prevention: Principles and Endpoints.- Risk Stratification forSsudden Death in Patients with Coronary Artery Disease.- Heart Failure and Sudden Death.- Neurological Conditions and Sudden Death.- Obstructive Sleep Apnea and Sudden Death.- Sudden Cardiac Death in Athletes.- Sudden Cardiac Death in Infancy: Focus on Prolonged Repolarization.- Sudden Cardiac Death in Kidney Diseases.