This timely volume addresses the areas of pathophysiology and therapy of pulmonary hypertension, which have seen exciting developments over the past decade. The discoveries of endothelin overexpression as well as prostacyclin and nitric oxide deficiency in association with pulmonary hypertension have led to important therapeutic insights. In addition, the identification of genes associated with pulmonary hypertension has just begun to open the door to new pathophysiologic insights. The new therapies have led to significant improvements in patient function, quality of life and survival.
This book will be of interest not only to cardiologists, pulmonary specialists and rheumatologists, but also many nurses and pharmacotherapists are becoming increasingly involved in the therapy of patients with pulmonary hypertension.
Chapter 1. Historical Perspective: A Century of Primary (Idiopathic) Pulmonary Hypertension.
Alfred P. Fishman MD
Chapter 2: Classification of Pulmonary Hypertension
C. William Hargett, MD and Victor F. Tapson, MD (2 Tables)
Chapter 3. Diagnostic Approach to Pulmonary Arterial Hypertension (1 figure)
Ronald J. Oudiz, MD, FACP, FACC
Chapter 4. Pathophysiology of Pulmonary Arterial Hypertension
Harrison W. Farber, M.D.
Chapter 5: Pulmonary Hypertension Genes (Check references)
Elisabeth Donlevy Willers, MD and Ivan M. Robbins, MD
Chapter 6. The Right Ventricle in Pulmonary Hypertension
Andrew C. Stone, MD and James R. Klinger, MD
Chapter 7. Congenital Heart Disease Associated Pulmonary Arterial Hypertension
Michael J. Landzberg, MD
Chapter 8. Connective Tissue Disease Associated Pulmonary Hypertension
Kimberly Fisher, MD, Nicholas S. Hill, MD and Harrison Farber, MD
Chapter 9. Pulmonary Hypertension associated with HIV, Liver Disease, Sarcoidosis and Sickle Cell Disease.
Kimberly A. Fisher, MD and Elizabeth S. Klings, MD
Chapter 10. Chronic Thromboembolic Pulmonary Hypertension
Victor J. Test, MD, William R. Auger, MD and Peter F. Fedullo, MD.
Chapter 11. General Therapeutic Approach and Traditional Therapies
Nicholas S. Hill, MD and Elizabeth Klings, MD
Chapter 12. Prostacyclin Therapy for Pulmonary Arterial Hypertension
Nicholas S. Hill MD, Todd F. Vardas, MD and Vallerie McLaughlin MD
Chapter 13. Endothelin and its blockade in pulmonary arterial hypertension
David Langleben, MD, FRCPC
Chapter 14. PDE 5 Inhibitors and the cGMP Pathway in Pulmonary Arterial Hypertension
Ioana R. Preston MD
Chapter 15. Statins for treatment of pulmonary hypertension
John L. Faul MD, Peter N. Kao MD, Toshihiko Nishimura MD, Arthur Sung MD, Hong Hu MD and Ronald G. Pearl MD, PhD
Chapter 16. Transitions and Combination Therapy for Pulmonary Arterial Hypertension
Todd Hirschtritt MD, M. Kathryn Steiner MD and Nicholas S. Hill MD
Chapter 17. Acute right ventricular dysfunction: focus on acute cor pulmonale Antoine Vieillard-Baron MD, François Jardin MD
Chapter 18. Lung transplantion and atrial septostomy for pulmonary arterial hypertension
E.P. Trulock MD
Chapter 19 : New Directions in Pulmonary Hypertension Therapy
Christopher M Carlin BSc (Hons) MB ChB (Hons) MRCP
Andrew J Peacock MD FRCP