Pharmacological Aspects of Heart Disease

1. Front Matter

   Pages i-xiv

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2. Antiarrhythmic Agents

   1. Front Matter

      Pages 1-1

      PDF

   2. Approaches to the Selection of an Antiarrhythmic Drug

      • Philip J. Podrid

      Pages 3-16

   3. Antiarrhythmic Action of Calcium Antagonists

      • L. Szekeres, J. Gy. Papp, Éva Udvary, Ágnes Végh

      Pages 17-31

   4. Quinidine Reduces Outward Current in Single Canine Cardiac Purkinje Cells

      • T. Nakayama, H. A. Fozzard

      Pages 33-44

   5. Antiarrhythmic Drug Therapy for Patients with Ventricular Tachyarrhythmias in the Setting of Left Ventricular Dysfunction: 1. The Role of Propafenone 2. The Role of Adjunct Beta-Blockade

      • M. A. Brodsky, B. J. Allen, C. Luckett, R. Thomas

      Pages 45-57

   6. Protective Effect of Nifedipine upon Ouabain-Induced Arrhythmias

      • S. Navaratnam, J. C. Khatter

      Pages 59-73

   7. Effect of Isoprenaline or Stress on Adrenaline-Induced Arrhythmias in Albino Rats

      • P. K. Das, S. Bhowmick

      Pages 75-86

3. Therapy of Hypertension and Heart Failure

   1. Front Matter

      Pages 87-87

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   2. Clinical Trials in Hypertension and Congestive Heart Failure

      • C. D. Furberg, J. A. Cutler, S. W. Macmahon, S. Yusuf

      Pages 89-95

   3. Interaction of Calcium Entry Blockers and Adrenergic System in Hypertension and Heart Failure

      • F. Fouad-Tarazi, R. Pedrinelli

      Pages 97-107

   4. Prazosin Therapy in Chronic Congestive Heart Failure

      • D. T. Mason, M. C. Chan, G. Lee

      Pages 109-118

   5. Influences of a Long-Term Treatment with Antihypertensive Drugs on Left Ventricular Myosin Isoenzyme Pattern in Spontaneously Hypertensive Rats

      • N. Takeda, M. Kanemura, K. Noma, T. Ohkubo, M. Nagano

      Pages 119-124

   6. Enhanced Action of Nifedipine upon Vascular Smooth Muscle from Hypertensive Rats

      • H. E. Cingolani, G. J. Rinaldi, E. Amado Cattaneo, A. Mattiazzi

      Pages 125-136

   7. Ajmaloon a Unique Herbal Polypharmaceutical Possessing Both Hypotensive and Cadmium Lowering Property

      • R. B. Arora, B. Bhatia, S. U. Khan, S. Roy, N. I. Ansari, S. A. Tamanna

      Pages 137-150

   8. Pathophysiology and Treatment of Decreased Cardiac Output Complicating Pulmonary Hypertension

      • R. M. Prewitt, J. Ducas

      Pages 151-161

4. Calcium Antagonists and Beta Adrenergic Receptor Blockers

   1. Front Matter

      Pages 163-163

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   2. Ca Antagonists in Cardiopulmonary Changes Induced by High Altitude Hypoxia

      • B. Ošťádal, F. Kolář, V. Pelouch, J. Procházka, J. Škovránek, D. Urbanová et al.

      Pages 165-177

   3. Effect of Crystalloid Cardioplegia and Diltiazem on the Cardiac Function and Some Biochemical Parameters During Hypothermic Cardiac Arrest Using Cardiopulmonary Bypass

      • Kailash Prasad, Baikunth Bharadwaj

      Pages 179-194

   4. Effects of Verapamil on Metabolism and Function of Hearts from Normal and Hyperthyroid Rats

      • M. E. Hess, N. Haugaard, A. Torbati

      Pages 195-203

The importance of heart and artery disease as a cause of death and disability is difficult to exaggerate: it causes over half of all deaths in the western world and now accounts for one-quarter of deaths in the entire world. This appalling incidence persists in spite of commendable progress in treatment and prevention, particularly in the last two or three decades. Deaths from coronary disease have decreased by a third in the past twenty years and stroke has decreased by a half in the same period. This remarkable improvement, saving thousands of lives per year, has come about due to changes in life style (low fat diet, control of high blood pressure, less smoking and more exercise) and progress in treatment (more effective drugs, coronary care units, pacemakers, and cardiac surgery). Progress in understanding the pathophysiologic and pharn,acologic mechanisms operative in heart disease have been paramount in the development of more rational and more effective therapy. Dramatic and spectacular surgical treatments have fired the public imagination. Bypass surgery is commonplace and results in complete or considerable relief of symptoms in the majority of patients operated upon.

• Bypass
• blood pressure
• cardiac function
• heart
• hypertension
• stroke

• Youville Research Institute, St. Boniface General Hospital and Faculty of Medicine, University of Manitoba, Winnipeg, Canada

  Robert E. Beamish, Vincenzo Panagia, Naranjan S. Dhalla

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