Cardiac Positron Emission Tomography

1. Front Matter

   Pages i-xxi

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2. Methodology

   1. Front Matter

      Pages 1-1

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   2. Trends in Instrumentation

      • Terry J. Spinks, Terry Jones

      Pages 3-47

   3. Attenuation Correction: Practical Considerations

      • Stephen L. Bacharach

      Pages 49-64

   4. Radiopharmaceuticals

      • Michael R. Kilbourn

      Pages 65-78

   5. Utility and Limitations of [18F]2-Deoxy-2-Fluoro-D-Glucose for the Assessment of Flux through Metabolic Pathways in Heart Muscle: A Critical Appraisal

      • Heinrich Taegtmeyer

      Pages 79-95

   6. Quantitative Evaluation of Myocardial Perfusion

      • Gary D. Hutchins, Markus Schwaiger

      Pages 97-118

3. Myocardial Perfusion Imaging

   1. Front Matter

      Pages 119-119

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   2. Assessment of Myocardial Perfusion with 13N-Ammonia or 82RB

      • Markus Schwaiger, Otto Muzik, Gary D. Hutchins

      Pages 121-146

   3. Assessment of Myocardial Perfusion with 15O-Water

      • Pilar Herrero, Steven R. Bergmann

      Pages 147-160

   4. 62Cu-PTSM: A Generator-Based Radiopharmaceutical for Myocardial Perfusion Imaging

      • Mark A. Green

      Pages 161-172

   5. Comparison of Cost-Effectiveness of Myocardial Perfusion Imaging Versus other Approaches: Predictions by a Model

      • Randolph E. Patterson, Steven F. Horowitz, Robert L. Eisner

      Pages 173-185

4. Assessment of Tissue Viability

   1. Front Matter

      Pages 187-187

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   2. Assessment of Blood Flow and Substrate Metabolism in the Myocardium of the Normal Human Heart

      • Heinrich R. Schelbert

      Pages 189-206

   3. Comparison of SPECT and PET for Assessment of Tissue Viability

      • Robert O. Bonow

      Pages 207-225

   4. 11C-Acetate in the Study of Ischemic Heart Disease

      • Robert J. Gropler

      Pages 227-240

   5. Assessment of Myocardial Viability Using 15O-Water

      • Hidehiro Iida, Ranil De Silva, Christopher G. Rhodes, Yoshikazu Tamura, Akira Takahashi, Denis Agostini et al.

      Pages 241-262

   6. Myocardial ⁸² RB Kinetics Identify Cell Membrane Integrity and Tissue Viability

      • Jürgen Vom Dahl, Markus Schwaiger

      Pages 263-277

   7. Imaging Hypoxic Myocardium

      • Gary V. Martin, John R. Grierson, James H. Caldwell

      Pages 279-293

5. Other Applications

   1. Front Matter

      Pages 295-295

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It is the mark of an instructed mind to rest satisfied with the degree of precision which the nature of the subject admits, and not to seek exactness where only an approximation of the truth is possible. Aristotle With the development of imaging techniques, the in vivo study of human anatomy and physiology has become possible with increasing "approximation of the truth. " Advances have been made not only in data acquisition, but also in processing as well as visualization of functional and morphological data. Following the successful application of planar two-dimensional imaging approaches, more recently three-dimensional data acquisition and correspond­ ing tomographic image reconstruction has become possible. With the rapid growth of computer support, advanced processing allows for user-friendly interaction with complex data sets. Classical x-ray imaging techniques have matured to excellent spatial resolution and contrast, which provide specific delineation of anatomical changes occurring in cardiovascular disease. In parallel, the use of tracer principles supported the successful introduction of nuclear medicine procedures for the functional characterization of physiology and pathophysiology. The application of such techniques were initially limited by relatively poor spatial resolution, but excelled in high sensitivity 30 years, scintigraphic imaging emerged from and specificity. In the last rectilinear scanning to planar gamma camera imaging and single-photon xvi Preface emISSIOn tomography (SPECT). Based on these advances and the experi­ mental success of autoradiography, the potential of scintigraphy as a clinical and research tool has been well appreciated.

• cardiology
• cardiovascular
• heart
• heart disease
• vascular disease

`... this book is highly recommendable for everybody involved in CPET. It is also a readable source of information not only to nuclear medicine physicists but also to cardiologists, cardiac surgeons, physiologists and clinical physicists and radiopharmacists. This book should gain widespread acceptance... The scientific accuracy is undoubtedly high; the quality of written contributions is perfect, as is the quality of all presented figures; there is also a chapter on color display.'
European Journal of Nuclear Medicine, 24:2 (1997)

• Department of Nuclear Medicine, Technical University in Munich, Munich, Germany

  Markus Schwaiger

• Division of Nuclear Medicine Department of Internal Medicine UMH B1 G412 / 0028, University of Michigan Medical Center, Ann Arbor, USA

  Markus Schwaiger

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