Concepts in Biochemical Pharmacology

1. Front Matter

   Pages I-XVI

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2. Routes of Drug Administration

   1. Biological Membranes and Their Passage by Drugs

      • C. Adrian M. Hogben

      Pages 1-8

   2. Absorption of Drugs from the Gastrointestinal Tract

      • L. S. Schanker

      Pages 9-24

   3. Buccal Absorption of Drugs

      • Arnold H. Beckett, R. D. Hossie

      Pages 25-46

   4. Subcutaneous and Intramuscular Injection of Drugs

      • Jens Schou

      Pages 47-66

   5. Absorption, Distribution and Excretion of Gaseous Anesthetics

      • H. Rackow

      Pages 67-87

   6. Aerosols

      • L. T. Greene

      Pages 88-102

   7. Absorption of Drugs through the Skin

      • Martin Katz, Boyd J. Poulsen

      Pages 103-174

3. Sites of Drug Transport and Disposition

   1. The Nature of Drug-Protein Interaction

      • W. Settle, S. Hegeman, R. M. Featherstone

      Pages 175-186

   2. Physical Methods for Studying Drug-Protein Binding

      • Colin F. Chignell

      Pages 187-212

   3. Effect of Binding to Plasma Proteins on the Distribution, Activity and Elimination of Drugs

      • P. Keen

      Pages 213-233

   4. Competition between Drugs and Normal Substrates for Plasma and Tissue Binding Sites

      • H. M. Solomon

      Pages 234-239

   5. Drug Entry into Brain and Cerebrospinal Fluid

      • David P. Rall

      Pages 240-248

   6. Translocation of Drugs into Bone

      • Harry Foreman

      Pages 249-257

   7. Translocation of Drugs and Other Exogenous Chemicals into Adipose Tissue

      • Lester C. Mark

      Pages 258-275

   8. Placental Transfer of Drugs and their Distribution in Fetal Tissues

      • Mieczyslaw Finster, Lester C. Mark

      Pages 276-285

   9. The Use of Autoradiography in Experimental Pharmacology

      • Lloyd J. Roth

      Pages 286-316

   10. Accumulation of Drugs at Sympathetic Nerve Endings

       • Irwin J. Kopin

       Pages 317-327

4. Sites of Drug Excretion

   1. Excretion of Drugs by the Kidney

      • I. M. Weiner

      Pages 328-353

   2. Excretion of Drugs in Bile

      • R. L. Smith

      Pages 354-389

This volume of the Handbook of Experimental Pharmacology (Concepts in Biochemical Pharmacology) will show that pharma­ cology has finally arrived as a true discipline in its own right, and is no longer the handmaiden of organic chemistry and physiology. Instead it is an amalgam of all the biological sciences including biochemistry, biophysical chemistry, physiology, pathology and clinical medicine. In the volumes that make up Concepts in Bioche­ mical Pharmacology we hope to convince Medical Schools what should now be obvious, that pharmacology is no longer that dull topic bridging the basic sciences with medicine, but is probably the most important subject in the medical curriculum. We are grateful for the advice of Dr. BYRON CLARKE, Director of the Pharmacology-Toxicology Program at the National Insti­ tutes of Health, whose support made possible much of the work described in this volume. Contents Section One: Routes of Drug Administration Chapter 1: Biological Membranes and Their Passage by Drugs. C. A. M. HOGBEN 1 References. . . . . . . . . . . . . . . . . . . . . . . . . . 8 Chapter 2: Absorption of Drugs from the Gastrointestinal Tract. L. S. SCHANKER. With 5 Figures. 9 I. Introduction. . . . . . . . . . . . . . . . . . . . . . . 9 II. Methods of Study. . . . . . . . . . . . . . . . . . . . . 9 III. Absorption from the Stomach . . . . . . . . . . . . . . . 11 IV. Intestinal Absorption of Non-Electrolytes and Weak Electrolytes 15 V. Absorption of Weak Electrolytes from the Colon and Rectum 18 VI. Intestinal Absorption of Organic Ions. . . . . . . . . . 19 VII. Intestinal Absorption of Macromolecules . . . . . . . . . . 19 VIII. Active Transport across the Intestinal Epithelium . . . . . 20 IX. Effect of EDTA on Drug Absorption from the Intestine . . . . . . .

• Biochemie
• Gesundheitsberichterstattung
• Pharmakologie
• absorption
• biochemistry
• chemistry
• drug
• medicine
• organic chemistry
• pathology
• pharmacology
• physiology
• toxicology

• Department of Health, Education and Welfare, National Institutes of Health, Bethesda, USA

  Bernard B. Brodie, James R. Gillette

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