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Medicine | Translational Research Methods for Diabetes, Obesity and Cardiometabolic… - A Focus on

Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development

A Focus on Early Phase Clinical Studies

Krentz, Andrew J., Heinemann, Lutz, Hompesch, Marcus (Eds.)

2015, XII, 312 p. 76 illus., 39 illus. in color.

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  • Provides a background to aid the understanding of drug effects and non-drug treatment strategies on key biochemical-hormonal defects of obesity and type 2 diabetes
  • Aids the selection of the most appropriate techniques for assessing insulin action, insulin secretion and body composition in humans​
  • Provides practical examples to assist usage/applications, explanation and study analysis
  • Perils and pitfalls are summarized for each technique

This book aims to aid the selection of the most appropriate techniques for use in early phase (1 and 2) clinical studies of new drugs for diabetes, obesity, and related cardiometabolic disease.

Clinical research methods for assessing the pharmacokinetics and pharmacodynamics of new diabetes drugs, e.g. the euglycaemic clamp technique, have become well-established in proof-of-mechanism studies; however, selection of the best techniques is by no means straightforward.

This book will aid the understanding of the need for new pharmacotherapies for type 1 diabetes, type 2 diabetes, and obesity and the molecular targets of drugs currently in development.  Emerging technologies including the omics disciplines are considered together with practical and ethical issues of early phase clinical trials in subjects with cardiometabolic disorders.

Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development  will be of interest to biomedical scientists, pharmacologists, academics involved in metabolic research and clinicians practicing in these specialties.

Content Level » Professional/practitioner

Keywords » cardiometabolic - efficacy - glucose clamp - insulin resistance - obesity - type 2 diabetes

Related subjects » Internal Medicine - Medicine - Pharmacology & Toxicology

Table of contents 

1. Review of physiology/pathophysiology.- 2. Methods for assessing insulin action in humans.- 3. Assessment of insulin secretion.- 4. Measurement of ectopic fat in liver and muscle using magnetic resonance spectroscopy.- 5. Isotopic tracers for the measurement of metabolic flux.- 6. Measuring food intake in clinical drug development.- 7. Measurement of energy expenditure.- 8. Assessment of body composition.- 9.  Assessment of cardiovascular safety of new diabetes drugs.

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