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Suppressing the Mind

Anesthetic Modulation of Memory and Consciousness

  • Book
  • © 2010

Overview

Editors:
  1. Anthony Hudetz

    1. Dept. Anesthesiology, Medical College of Wisconsin, Milwaukee, U.S.A.

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    You can also search for this editor in PubMed   Google Scholar

  2. Robert Pearce

    1. Dept. Anesthesiology, University of Wisconsin-Madison, Madison, U.S.A.

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Multidisciplinary collection of original results and authoritative overviews of the current state of knowledge
  • Written by investigators internationally known for their significant contribution to the current understanding of the mechanism of anesthesia
  • Bridges molecular, cellular, integrative and systems-level actions of anesthetics with respect to their effects on consciousness and memory
  • Includes supplementary material: sn.pub/extras

Part of the book series: Contemporary Clinical Neuroscience (CCNE)

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-x
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  2. Introduction

    • Anthony Hudetz, Robert Pearce
    Pages 1-9

  3. Molecular Targets of General Anesthetics in the Nervous System

    • Hugh C. Hemmings Jr
    Pages 11-31

  4. A Neurochemical Perspective on States of Consciousness

    • Christopher J. Watson, Helen A. Baghdoyan, Ralph Lydic
    Pages 33-80

  5. Anesthetic Modulation of Auditory Perception: Linking Cellular, Circuit, and Behavioral Effects

    • Matthew I. Banks
    Pages 81-97

  6. Cortical Disintegration Mechanism of Anesthetic-Induced Unconsciousness

    • Anthony Hudetz
    Pages 99-125

  7. Anesthesia and the Thalamocortical System

    • Michael T. Alkire
    Pages 127-138

  8. Anesthesia-Induced State Transitions in Neuronal Populations

    • Jamie Sleigh, Moira Steyn-Ross, Alistair Steyn-Ross, Logan Voss, Marcus Wilson
    Pages 139-160

  9. Anesthesia Awareness: When the Mind Is Not Suppressed

    • George A. Mashour
    Pages 161-173

  10. Loss of Recall and the Hippocampal Circuit Effects Produced by Anesthetics

    • M. Bruce MacIver
    Pages 175-192

  11. Modulation of the Hippocampal θ-Rhythm as a Mechanism for Anesthetic-Induced Amnesia

    • Misha Perouansky, Robert Pearce
    Pages 193-214

  12. Propofol Amnesia – What is Going on in the Brain?

    • Robert A. Veselis, Kane O. Pryor
    Pages 215-243

  13. Back Matter

    Pages 242-252
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Keywords

About this book

Anesthetics produce a reversible state of unconsciousness accompanied by ante- grade amnesia. This remarkable phenomenon brings great relief to surgical patients and wonder to clinicians and scientists. To date, we do not fully understand the mechanisms by which anesthetics ablate conscious sensation and memory. We are, however, making progress. This book presents original results as well as overviews of the current state of knowledge of the problem. It is authored by investigators who know the ?eld well; their research at a number of levels has contributed substantially to our c- rent understanding of anesthetic modulation of memory and consciousness. Most of the contributors were presenters at two workshops organized by Dr. Pearce and Dr. Hudetz at the 40th Annual Winter Conference on Brain Research, held at Snowmass Village, Colorado, from January 27 through February 2, 2007. One workshop focused on anesthetic modulation of consciousness and another on an- thetic modulation of memory. Seven of the chapters are based on material presented at these symposia – appropriately updated with new relevant ?ndings. This infor- tion is supplemented by chapters on anesthesia and sleep, computational analysis of the state of anesthesia, and the clinical phenomenon of “anesthesia awareness,” a topic that has recently received much public attention. With these three additional contributions, the book thus includes 10 chapters.

Reviews

From the reviews:

“The editors present this book as the first book with a unified view of studies on anaesthetic modulation on both consciousness and memory to bridge molecular, cellular, integrative, and systems-level effects. … even the heavy technical information in the book is written in the style for a wider audience ― such as the JCS/Tucson toward-a-science-of-consciousness crowd.” (Bill Faw, Journal of Consciousness Studies, Vol. 18 (3-4), 2011)

“This is a compilation of 10 essays on the neuroscientific underpinnings of general anesthesia. … intended for anesthesia researchers, but the quality and the clarity of the writing make it accessible and interesting for anyone involved in clinical anesthesia care. … I found this book extremely enlightening. The authors have successfully presented the current state of scientific understanding in a way that appeals to clinical practitioners. I highly recommend this book to anyone who wants to gain a better understanding of how general anesthetics work.” (David B. Glick, Doody’s Review Service, May, 2010)

Editors and Affiliations

  • Dept. Anesthesiology, Medical College of Wisconsin, Milwaukee, U.S.A.

    Anthony Hudetz

  • Dept. Anesthesiology, University of Wisconsin-Madison, Madison, U.S.A.

    Robert Pearce

Bibliographic Information

  • Book Title: Suppressing the Mind

  • Book Subtitle: Anesthetic Modulation of Memory and Consciousness

  • Editors: Anthony Hudetz, Robert Pearce

  • Series Title: Contemporary Clinical Neuroscience

  • DOI: https://doi.org/10.1007/978-1-60761-462-3

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Humana Press 2010

  • Hardcover ISBN: 978-1-60761-463-0Published: 18 December 2009

  • Softcover ISBN: 978-1-61779-678-4Published: 25 February 2012

  • eBook ISBN: 978-1-60761-462-3Published: 10 March 2010

  • Series ISSN: 2627-535X

  • Series E-ISSN: 2627-5341

  • Edition Number: 1

  • Number of Pages: X, 252

  • Number of Illustrations: 19 b/w illustrations, 19 illustrations in colour

  • Topics: Anesthesiology, Human Physiology, Neurosciences, Neurology

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