mODa 9 – Advances in Model-Oriented Design and Analysis

1. Front Matter

   Pages i-xxv

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2. Impact of Stratified Randomization in Clinical Trials

   • Vladimir V. Anisimov

   Pages 1-8

3. The Non-Uniqueness of Some Designs for Discriminating Between Two Polynomial Models in One Variable

   • Anthony C. Atkinson

   Pages 9-16

4. Covariate Adjusted Designs for Combining Efficiency, Ethics and Randomness in Normal Response Trials

   • Alessandro Baldi Antognini, Maroussa Zagoraiou

   Pages 17-24

5. Split-Plot and Robust Designs: Weighting and Optimization in the Multiple Response Case

   • Rossella Berni

   Pages 25-32

6. An Improvement in the Lack-of-Fit Optimality of the (Absolutely) Continuous Uniform Design in Respect of Exact Designs

   • Wolfgang Bischoff

   Pages 33-39

7. Optimal Allocation Proportion for a Two-Treatment Clinical Trial Having Correlated Binomial Responses

   • Atanu Biswas, Saumen Mandal

   Pages 41-48

8. Sample Size Determination for Multivariate Performance Analysis with Complex Designs

   • Stefano Bonnini, Livio Corain, Luigi Salmaso

   Pages 49-55

9. Optimal Design for Compositional Data

   • Roelof L. J. Coetzer, Linda M. Haines

   Pages 57-64

10. Dose Finding Experiments: Responses of Mixed Type

    • Valerii V. Fedorov, Yuehui Wu, Rongmei Zhang

    Pages 65-72

11. Pharmacokinetic Studies Described by Stochastic Differential Equations: Optimal Design for Systems with Positive Trajectories

    • Valerii V. Fedorov, Sergei L. Leonov, Vyacheslav A. Vasiliev

    Pages 73-80

12. On Testing Hypotheses in Response-Adaptive Designs Targeting the Best Treatment

    • Nancy Flournoy, Caterina May, Jose A. Moler, Fernando Plo

    Pages 81-88

13. Towards Gaussian Process-based Optimization with Finite Time Horizon

    • David Ginsbourger, Rodolphe Le Riche

    Pages 89-96

14. Optimal Designs for Linear Logistic Test Models

    • Ulrike Graßhoff, Heinz Holling, Rainer Schwabe

    Pages 97-104

15. A Class of Screening Designs Robust to Active Second-Order Effects

    • Bradley Jones, Christopher J. Nachtsheim

    Pages 105-112

16. D-Optimal Design for a Five-Parameter Logistic Model

    • Zorayr Manukyan, William F. Rosenberger

    Pages 113-120

17. Sequential Barycentric Interpolation

    • Hugo Maruri-Aguilar, Paula Camelia Trandafir

    Pages 121-128

18. Some Considerations on the Fisher Information in Nonlinear Mixed Effects Models

    • Tobias Mielke, Rainer Schwabe

    Pages 129-136

19. Designs with High Breakdown Point in Nonlinear Models

    • Christine H. Müller, Christina Schäfer

    Pages 137-144

20. A Note on the Relationship between Two Approaches to Optimal Design under Correlation

    • Andrej Pázman, Werner G. Müller

    Pages 145-148

The volume contains the proceedings of the 9th Workshop on Model-Oriented Design and Analysis. It offers leading and pioneering work on optimal experimental designs, both from a theoretical point of view and in respect of real applications. Scientists from Eastern and Western Europe, the US, Asia and Africa, are contributors to this volume. Designs for nonlinear models, for discriminating between models, for multivariate data and for applications to medicine are some of the primary topics covered.

• Chemical Models
• Clinical Trials
• Generalized Linear Models
• Latent variable model
• Nonlinear Models
• Optimal Experimental Cesigns
• Random variable
• best fit
• test theory

From the reviews:

“The volume is a set of 30 articles strongly connected to the talks presented at the 9th International Workshop in Model-Oriented Design and Analysis. … It offers the model-oriented approach to optimality of designs from theoretical point of view and gives real examples in many areas of applications. … it presents the latest trends in optimal experimental designs research. The concepts in the book are presented in a very reader-friendly way, with many examples. … highly recommended for anyone interested in design of experiments.” (Katarzyna Filipiak, International Statistical Review, Vol. 79 (3), 2011)

• Dipt. di Scienze Statistiche, University of Bologna, Bologna, Italy

  Alessandra Giovagnoli

• and Political Science, Department of Statistics, London School Economics, London, United Kingdom

  Anthony C. Atkinson

• Department of Statistics, University of Glasgow, Glasgow, United Kingdom

  Bernard Torsney

• , SEMEQ, Università del Piemonte Orientale, Novara, Italy

  Caterina May

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