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  • Book
  • © 2008

Modern Genome Annotation

The Biosapiens Network

  • Cutting-edge genome analysis methods from leading bioinformaticians

  • Includes supplementary material: sn.pub/extras

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Table of contents (20 chapters)

  1. Front Matter

    Pages I-XVIII
  2. Introduction BIOSAPIENS: A European Network of Excellence to develop genome annotation resources

  3. Gene definition

    1. Front Matter

      Pages 5-5
    2. State of the art in eukaryotic gene prediction

      • T. Alioto, R. Guigó
      Pages 7-39
    3. Quality control of gene predictions

      • A. Nagy, H. Hegyi, K. Farkas, H. Tordai, E. Kozma, L. Bányai et al.
      Pages 41-52
  4. Gene regulation and expression

    1. Front Matter

      Pages 53-53
    2. Evaluating the prediction of cis-acting regulatory elements in genome sequences

      • O. Sand, J.-V. Turatsinze, J. van Helden
      Pages 55-89
    3. A biophysical approach to large-scale protein-DNA binding data

      • T. Manke, H. Roider, M. Vingron
      Pages 91-103
    4. From gene expression profiling to gene regulation

      • R. Coulson, T. Manke, K. Palin, H. Roider, O. Sand, J. van Helden et al.
      Pages 105-119
  5. Annotation and genetics

    1. Front Matter

      Pages 121-121
  6. Functional annotation of proteins

    1. Front Matter

      Pages 137-137
    2. Resources for functional annotation

      • A. J. Bridge, A.-Lise Veuthey, N. J. Mulder
      Pages 139-164
    3. Annotating bacterial genomes

      • C. Médigue, A. Danchin
      Pages 165-190
    4. Data mining in genome annotation

      • I. Artamonova, S. Kramer, D. Frishman
      Pages 191-212
    5. Modern genome annotation: the BioSapiens network

      • C. Yeats, Ch. Orengo, A. Lise Veuthey, B. Boeckmann, L. Juhl Jensen, A. Valencia et al.
      Pages 213-238
    6. Structure to function

      • J. D. Watson, J. M. Thornton, M. L. Tress, G. Lopez, A. Valencia, O. Redfern et al.
      Pages 239-262
    7. Harvesting the information from a family of proteins

      • B. Vroling, G. Vriend
      Pages 263-279
  7. Protein structure prediction

    1. Front Matter

      Pages 281-281
    2. Structure prediction of globular proteins

      • A. Tramontano, D. Jones, L. Rychlewski, R. Casadio, P. Martelli, D. Raimondo et al.
      Pages 283-307

About this book

An accurate description of current scientific developments in the field of bioinformatics and computational implementation is presented by research of the BioSapiens Network of Excellence. Bioinformatics is essential for annotating the structure and function of genes, proteins and the analysis of complete genomes and to molecular biology and biochemistry.

Included is an overview of bioinformatics, the full spectrum of genome annotation approaches including; genome analysis and gene prediction, gene regulation analysis and expression, genome variation and QTL analysis, large scale protein annotation of function and structure, annotation and prediction of protein interactions, and the organization and annotation of molecular networks and biochemical pathways. Also covered is a technical framework to organize and represent genome data using the DAS technology and work in the annotation of two large genomic sets: HIV/HCV viral genomes and splicing alternatives potentially encoded in 1% of the human genome.

Editors and Affiliations

  • Wissenschaftszentrum Weihenstephan, TU München, Freising, Germany

    Dmitrij Frishman

  • Structural and Computational Programme, Spanish National Cancer Research Centre, Madrid, Spain

    Alfonso Valencia

Bibliographic Information

Buy it now

Buying options

eBook USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access