Logo - springer
Slogan - springer

Life Sciences - Systems Biology and Bioinformatics | Computational Methods in Synthetic Biology

Computational Methods in Synthetic Biology

Series: Methods in Molecular Biology, Vol. 1244

Marchisio, Mario Andrea (Ed.)

2015, XI, 358 p. 136 illus., 43 illus. in color.

A product of Humana Press
Available Formats:

Springer eBooks may be purchased by end-customers only and are sold without copy protection (DRM free). Instead, all eBooks include personalized watermarks. This means you can read the Springer eBooks across numerous devices such as Laptops, eReaders, and tablets.

You can pay for Springer eBooks with Visa, Mastercard, American Express or Paypal.

After the purchase you can directly download the eBook file or read it online in our Springer eBook Reader. Furthermore your eBook will be stored in your MySpringer account. So you can always re-download your eBooks.


(net) price for USA

ISBN 978-1-4939-1878-2

digitally watermarked, no DRM

Included Format: PDF and EPUB

download immediately after purchase

learn more about Springer eBooks

add to marked items


Hardcover version

You can pay for Springer Books with Visa, Mastercard, American Express or Paypal.

Standard shipping is free of charge for individual customers.


(net) price for USA

ISBN 978-1-4939-1877-5

free shipping for individuals worldwide

usually dispatched within 3 to 5 business days

add to marked items

  • Gives complete coverage of the computational approaches currently used in Synthetic Biology
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts

This volume provides complete coverage of the computational approaches currently used in Synthetic Biology.  Chapters focus on computational methods and algorithms for the design of bio-components, insight on CAD programs, analysis techniques, and distributed systems. Written in the highly successful Methods in Molecular Biology series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory.


Authoritative and practical, Computational Methods in Synthetic Biology serves as a guide to plan in silico the in vivo or in vitro construction of a variety of synthetic bio-circuits.


Content Level » Professional/practitioner

Keywords » CAD programs - DNA Parts - DNA assembly protocols - RNA devices - algorithms - bio-components - computational methods - distributed systems - gene circuit in silico - synthetic network

Related subjects » Systems Biology and Bioinformatics

Table of contents 

Part I: Component Design

1. Computational Protein Design Methods for Synthetic Biology

Pablo Carbonell and  Jean-Yves Trosset

 2. Computer-Aided Design Of DNA Origami Structures

Denis Selnihhin and Ebbe Sloth Andersen


3. Computational Design Of RNA Parts, Devices, and Transcripts With Kinetic Folding Algorithms Implemented On Multiprocessor Clusters

Tim Thimmaiah, William E. Voje Jr., and James M. Carothers


4. Regulatory RNA Design Through Evolutionary Computation And Strand Displacement

William Rostain, Thomas E. Landrain, Guillermo Rodrigo, and Alfonso Jaramillo


Part II: Circuit Design

5.  Programming Languages for Circuit Design

Michael Pedersen and Boyan Yordanov


6. Kappa Rule-Based Modelling in Synthetic Biology

John Wilson-Kanamori, Vincent Danos, Ty Thomson, and Ricardo Honorato-Zimmer


7. Modular Design Of Synthetic Gene Circuits With Biological Parts and Pools                

Mario Andrea Marchisio


8. Computationally Guided Design Of Robust Gene Circuits

Najaf A. Shah and Casim A. Sarkar


9. Chemical Master Equation Closure for Computer-Aided Synthetic Biology

Patrick Smadbeck and Yiannis N. Kaznessis


10. Feedback loops in biological networks

Elisa Franco and Kate E. Galloway



Part III: Circuit Analysis and Simulations

11. Efficient Analysis Methods in Synthetic Biology

Curtis Madsen, Chris Myers, Nicholas Roehner, Chris Winstead, and Zhen Zhang


12. Using Computational Modeling and Experimental Synthetic Perturbations to Probe Biological Circuits

Joshua R. Porter and Eric Batchelor


13. In Silico Control Of Biomolecular Processes

Jannis Uhlendorf, Agnès Miermont, Thierry Delaveau, Gilles Charvin, François Fages, Samuel Bottani, Pascal Hersen, and  Gregory Batt


14. Stochastic Modular Analysis For Gene Circuits: Interplay Among Retroactivity, Nonlinearity, and Stochasticity

Kyung Hyuk Kim and Herbert M Sauro


Part IV: Distributed Systems and Automation


15. Distributed Model Construction with Virtual Parts

Michael T. Cooling and Tommy Yu


16. The Synthetic Biology Open Language

Chris Myers, Kevin Clancy, Goksel Misirli, Ernst Oberortner, Matthew Pocock,

Jacqueline Quinn, Nicholas Roehner, and Herbert Sauro


17. Computational Methods For The Construction, Editing, and Error Correction Of DNA Molecules And Their Libraries

Ofir Raz and Tuval Ben Yehezkel


Popular Content within this publication 



Read this Book on Springerlink

Services for this book

New Book Alert

Get alerted on new Springer publications in the subject area of Bioinformatics.