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Prokaryotic Toxin-Antitoxins

  • Book
  • © 2013

Overview

Editors:
  1. Kenn Gerdes

    1. Inst. for Cell and Molecular Bioscience, Centre for Bacterial Cell Biology, Newcastle University, Newcastle upon Tyne, United Kingdom

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  • Prokaryotic Toxin-Antitoxins gives a brief and clear overview of a complex and rapidly expanding research field of scientific, biotechnological and medical importance
  • Written by experts
  • With numerous colour illustrations ?
  • Includes supplementary material: sn.pub/extras

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-viii
    Download chapter PDF

  2. Introduction

    • Kenn Gerdes
    Pages 1-8

  3. Type I Toxin-Antitoxin Loci: hok/sok and fst

    • Keith Weaver
    Pages 9-26

  4. Novel Type I Toxin-Antitoxins Loci

    • Elizabeth Fozo
    Pages 27-43

  5. Type II Toxin-Antitoxin Loci: The ccdAB and parDE Families

    • Marie Deghorain, Nathalie Goeders, Thomas Jové, Laurence Van Melderen
    Pages 45-67

  6. Type II Toxin-Antitoxins Loci: The relBE Family

    • Kenn Gerdes
    Pages 69-92

  7. Type II Toxin-Antitoxin Loci: The Unusual mqsRA Locus

    • Niilo Kaldalu, Villu Kasari, Gemma Atkinson, Tanel Tenson
    Pages 93-105

  8. Type II Toxin-Antitoxin Loci: The mazEF Family

    • Yoshihiro Yamaguchi, Masayori Inouye
    Pages 107-136

  9. Type II Toxin-Antitoxins: Structural and Functional Aspects of Type II Loci in Mycobacteria

    • Vickery L. Arcus, Gregory M. Cook
    Pages 137-156

  10. Type II Toxin-Antitoxin Loci: The phd/doc Family

    • Abel Garcia-Pino, Yann Sterckx, Roy D. Magnuson, Remy Loris
    Pages 157-176

  11. Type II Toxin-Antitoxin Loci: The fic Family

    • Arnaud Goepfert, Alexander Harms, Tilman Schirmer, Christoph Dehio
    Pages 177-187

  12. Type II Toxin-Antitoxin Loci, hipBA and Persisters

    • Kim Lewis, Sonja Hansen
    Pages 189-203

  13. Type II Toxin-Antitoxin Loci: The Epsilon/zeta Family

    • Hannes Mutschler, Anton Meinhart
    Pages 205-223

  14. Archaeal Type II Toxin-Antitoxins

    • Shiraz A. Shah, Roger A. Garrett
    Pages 225-238

  15. Type II Toxin-Antitoxin Loci: Phylogeny

    • Hong-Yu Ou, Yiqing Wei, Dexi Bi
    Pages 239-247

  16. Type III Toxin-Antitoxin Loci

    • Tim R. Blower, Francesca L. Short, George P. C. Salmond
    Pages 249-265

  17. Type II Toxin-Antitoxin Loci Encoded by Plasmids

    • Elizabeth Diago-Navarro, Ana M. Hernández-Arriaga, Ramón Díaz-Orejas
    Pages 267-294

  18. Toxin-Antitoxin Loci in Mycobacterium tuberculosis

    • Ambre Sala, Patricia Bordes, Gwennaele Fichant, Pierre Genevaux
    Pages 295-314

  19. Toxin-Antitoxin Loci in Streptococcus pneumoniae

    • Wai Ting Chan, Inma Moreno-Córdoba, Chew Chieng Yeo, Manuel Espinosa
    Pages 315-339

  20. Biotechnological and Medical Exploitations of Toxin-Antitoxin Genes and Their Components

    • Guillermo de la Cueva-Méndez, Belén Pimentel
    Pages 341-360
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Keywords

About this book

Prokaryotic Toxins – Antitoxins gives the first overview of an exciting and rapidly expanding research field. Toxin – antitoxin (TA) genes were discovered on plasmids 30 years ago. Since then it has become evident that TA genes are highly abundant in bacterial and archaeal chromosomes. TA genes code for an antitoxin that combine with and neutralize a cognate toxin. When activated, the toxins inhibit protein synthesis and cell growth and thereby induce dormancy and multidrug tolerance (persistence). Remarkably, in some species, the TA gene families have undergone dramatic expansions. For example, the highly persistent major human pathogen Mycobacterium tuberculosis has »100 TA loci. The large expansion of TA genes by some organisms is a biological mystery. However, recent observations indicate that TA genes contribute cumulatively to the persistence of bacteria. This medically important phenomenon may thus for the first time become experimentally tractable at the molecular level.

Editors and Affiliations

  • Inst. for Cell and Molecular Bioscience, Centre for Bacterial Cell Biology, Newcastle University, Newcastle upon Tyne, United Kingdom

    Kenn Gerdes

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