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DNA Replication Control in Microbial Cell Factories

  • Book
  • © 2015

Overview

Authors:
  1. Monika Glinkowska

    1. Dept Mol. Biology, University of Gdansk, Gdansk, Poland

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  2. Lidia Boss

    1. Dept Molecular Biology, University of Gdansk, Gdansk, Poland

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  3. Grzegorz Wegrzyn

    1. Dept Mol. Biology, University of Gdansk, Gdansk, Poland

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  • Unique analysis of the current knowledge on the control of DNA synthesis
  • Discussion of unexpected discoveries in the field of the control of genetic material replication
  • Description of links between metabolism, transcription and replication
  • Original hypotheses on mechanisms leading to carcinogenesis
  • Includes supplementary material: sn.pub/extras

Part of the book series: SpringerBriefs in Microbiology (BRIEFSMICROBIOL)

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Table of contents (1 chapter)

  1. Front Matter

    Pages i-v
    Download chapter PDF

  2. DNA Replication Control in Microbial Cell Factories

    • Monika Glinkowska, Lidia Boss, Grzegorz WÄ™grzyn
    Pages 1-36

  3. Back Matter

    Pages 37-50
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Keywords

About this book

This work describes the current knowledge of biochemical mechanisms regulating initiation of DNA replication in Escherichia coli, which focuses on the control of  activity of the DnaA protein. Examples of direct linkages between DNA replication and other cellular processes are provided. In addition, similarities of the mechanisms of regulation of DNA replication operating in prokaryotic and eukaryotic cells are identified, and implications for understanding more complex processes, like carcinogenesis are suggested.

Studies of recent years provided evidence that regulation of DNA replication in bacteria is more complex than previously anticipated. Multiple layers of control seem to ensure coordination of this process with the increase of cellular mass and the division cycle. Metabolic processes and membrane composition may serve as points where integration of genome replication with growth conditions occurs. It is also likely that coupling of  DNA synthesis with cellular metabolism may involve interactions of replication proteins with other macromolecular complexes, responsible for various cellular processes. Thus, the exact set of factors participating in triggering the replication initiation may differ depending on growth conditions. Therefore, understanding the regulation of DNA duplication requires placing this process in the context of the current knowledge on bacterial metabolism, as well as cellular and chromosomal structure. Moreover, in both Escherichia coli and eukaryotic cells, replication initiator proteins were shown to play other roles in addition to driving the assembly of replication complexes, which constitutes another, yet not sufficiently understood, layer of coordinating DNA replication with the cellcycle.

Authors and Affiliations

  • Dept Mol. Biology, University of Gdansk, Gdansk, Poland

    Monika Glinkowska, Grzegorz Wegrzyn

  • Dept Molecular Biology, University of Gdansk, Gdansk, Poland

    Lidia Boss

Bibliographic Information

  • Book Title: DNA Replication Control in Microbial Cell Factories

  • Authors: Monika Glinkowska, Lidia Boss, Grzegorz Wegrzyn

  • Series Title: SpringerBriefs in Microbiology

  • DOI: https://doi.org/10.1007/978-3-319-10533-8

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Author(s) 2015

  • Softcover ISBN: 978-3-319-10532-1Published: 07 October 2014

  • eBook ISBN: 978-3-319-10533-8Published: 23 September 2014

  • Series ISSN: 2191-5385

  • Series E-ISSN: 2191-5393

  • Edition Number: 1

  • Number of Pages: V, 50

  • Number of Illustrations: 4 illustrations in colour

  • Topics: Microbiology, Applied Microbiology, Cell Biology

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