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Life Sciences - Microbiology | Iron Acquisition by the Genus Mycobacterium - History, Mechanisms, Role of Siderocalin, Anti-Tuberculosis

Iron Acquisition by the Genus Mycobacterium

History, Mechanisms, Role of Siderocalin, Anti-Tuberculosis Drug Development

Byers, B. Rowe (Ed.)

2013, V, 92 p. 39 illus., 9 illus. in color.

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  • About this book

  • Demonstrates how iron sources can be used by Mycobacterium tuberculosis and other mycobacteria

Iron Acquisition by the Genus Mycobacterium summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described.  The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are discussed.  The potential role of siderocalin in iron gathering by M. tuberculosis is featured. Because new drugs for M. tuberculosis are needed, this brief also emphasizes the design of antibiotics that interfere with siderophore biosynthesis and the use of siderophore analogs and/or conjugates.

Content Level » Research

Keywords » Antibiotic Development - Haem Iron - Heme Iron - Iron Sources Organisms - M. Tuberculosis - Mycobacterial Disease - Siderocalin Enterobactin - Siderophores Iron Transporter

Related subjects » Inorganic Chemistry - Internal Medicine - Microbiology - Organic Chemistry

Table of contents 

A History of Iron Metabolism in the Mycobacteria.- Mycobacterial Iron Uptake Mechanisms.- Siderocalin Combats Mycobacterial Infections.- Design of Anti-TB Drugs Using the Iron Uptake Platform.

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