Biofilm Infections

1. Front Matter

   Pages i-xiv

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2. Introduction to Biofilms

   • Thomas Bjarnsholt

   Pages 1-9

3. Chronic Wound Colonization, Infection, and Biofilms

   • Klaus Kirketerp-Møller, Karen Zulkowski, Garth James

   Pages 11-24

4. The Relation of Biofilms to Chronic Otitis Media and Other Ear-Related Chronic Infections

   • Preben Homøe, Helle Krogh Johansen

   Pages 25-34

5. Human Oral Bacterial Biofilms: Composition, Dynamics, and Pathogenesis

   • Robert J. Palmer Jr, Richard Darveau, Richard J. Lamont, Bente Nyvad, Ricardo P. Teles

   Pages 35-68

6. Implant-Associated Infection

   • Werner Zimmerli, Andrej Trampuz

   Pages 69-90

7. The Role of Bacterial Biofilms in Infections of Catheters and Shunts

   • Trine Rolighed Thomsen, Luanne Hall-Stoodley, Claus Moser, Paul Stoodley

   Pages 91-109

8. Osteomyelitis

   • Graeme A. O’May, Rebecca A. Brady, Ranjani Prabhakara, Jeff G. Leid, Jason H. Calhoun, Mark E. Shirtliff

   Pages 111-137

9. The Importance of Biofilms in Chronic Rhinosinusitis

   • Jeff G. Leid, Emily K. Cope, Stacy Parmenter, Mark E. Shirtliff, Scot Dowd, Randall Wolcott et al.

   Pages 139-160

10. Helicobacter pylori and Biofilm Formation

    • Lone Rasmussen, Leif Percival Andersen

    Pages 161-166

11. Pseudomonas aeruginosa Biofilms in the Lungs of Cystic Fibrosis Patients

    • Niels Høiby, Helle Krogh Johansen, Claus Moser, Oana Ciofu, Peter Østrup Jensen, Mette Kolpen et al.

    Pages 167-184

12. Innate Immune Response to Infectious Biofilms

    • Peter Østrup Jensen, Claus Moser

    Pages 185-200

13. Adaptive Immune Responses and Biofilm Infections

    • Claus Moser, Peter Østrup Jensen

    Pages 201-214

14. Antibiotic Tolerance and Resistance in Biofilms

    • Oana Ciofu, Tim Tolker-Nielsen

    Pages 215-229

15. Novel and Future Treatment Strategies

    • Morten Alhede, Tim Holm Jakobsen, Michael Givskov

    Pages 231-249

16. Different Methods for Culturing Biofilms In Vitro

    • S. Brook Peterson, Yasuhiko Irie, Bradley R. Borlee, Keiji Murakami, Joe J. Harrison, Kelly M. Colvin et al.

    Pages 251-266

17. In Vivo Models of Biofilm Infection

    • Kendra P. Rumbaugh, Nancy L. Carty

    Pages 267-290

18. Summary and Perspectives

    • Thomas Bjarnsholt, Peter Østrup Jensen, Claus Moser, Niels Høiby

    Pages 291-294

19. Back Matter

    Pages 295-314

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This book will cover both the evidence for biofilms in many chronic bacterial infections as well as the problems facing these infections such as diagnostics and treatment regimes. A still increasing interest and emphasis on the sessile bacterial lifestyle biofilms has been seen since it was realized that that less than 0.1% of the total microbial biomass lives in the planktonic mode of growth. The term was coined in 1978 by Costerton et al. who defined the term biofilm for the first time.In 1993 the American Society for Microbiology (ASM) recognised that the biofilmmode of growth was relevant to microbiology. Lately many articles have been published on the clinical implications of bacterial biofilms. Both original articles and reviews concerning the biofilm problem are available.

• Faculty of Health Sciences, Department of International Health, Immu, University of Copenhagen, Copenhagen Ø, Denmark

  Thomas Bjarnsholt, Niels Høiby

• Afsnit 9301, Department Clinical Microbiology, H:S Rigshospitalet, Copenhagen Ø, Denmark

  Peter Østrup Jensen

• Afsnit 9301, Department for Clinical Microbiology, H:S Rigshospitalet, Copenhagen Ø, Denmark

  Claus Moser

About the Editors: Thomas Bjarnsholt, Ph.D., Technical University of Denmark, Lyngby, Denmark 
Peter Oestrup Jensen, Dept. of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark 
Claus Moser, Ph.D., Dept. of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark 
Niels Hoeby, Dept. of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark

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