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Life Sciences - Microbiology | Legionella Pneumophila: Pathogenesis and Immunity

Legionella Pneumophila: Pathogenesis and Immunity

Hoffman, Paul, Friedman, Herman, Bendinelli, Mauro (Eds.)

2008, XVIII, 208 p.

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  • Brings together all of the latest research on Legionella pneumophila, an emerging human pathogen
  • Interest in this area is rapidly growing
  • Edited by a long-term expert in the field of Legionella
  • Features the work of distinguished and internationally recognized leaders in the field who contribute chapters in their respective areas of expertise

The volume brings together all of the latest research on this pathogen, the interest in which is rapidly growing.

Legionella pneumophila is an emerging human pathogen that resides in natural environments as a parasite of freshwater.

There have been major new developments in this field, including the publication of three whole genome sequences and the discovery of a developmental cycle and novel cyst-like highly infectious form.

The bacteria have been used as a probe for macrophage cellular function to unravel fundamental new knowledge in the area of cellular biology.

Legionella has also become a model system for the study of innate as well as adaptive immunity.

Information on Legionella continues to increase in the U.S. and abroad, with Columbia University starting the first Legionella Genome Project with a multi-million dollar grant from the NIH.

In addition, The European Working Group for Legionella infections was formed in 1986. Members are scientists with an interest in improving knowledge and information on the clinical and environmental aspects of legionnaires' disease through developments in diagnosis, management and treatme

Content Level » Research

Keywords » Atmen - bacteria - infection - infections - infectious - physiology - protein

Related subjects » Immunology - Internal Medicine - Microbiology

Table of contents 

Legionella pneumophila Pathogenesis: Lessons Learned from Genomics.- Iron Assimilation and Type II Protein Secretion.- The Dot/Icm Type IVB Secretion System.- Life Cycle, Growth Cycles and Developmental Cycle of Legionella pneumophila.- Legionella in the Environment.- Regulation of the Legionella pneumophila Life Cycle.- Microbial Physiology.- Legionnaires’ Disease—Clinical Picture.- Legionella pneumophila:Innate and Adaptive Immunity.- Nonspecific Stimulation of Immunity Against Legionella.- Interaction of Legionella pneumophila with Amoeba.

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