Listeria monocytogenes: Pathogenesis and Host Response

1. Front Matter

   Pages I-XII

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2. A 20-Year Perspective on Listeria monocytogenes Pathogenesis

   • Daniel A. Portnoy

   Pages 1-12

3. Listeriosis

   • Bennett Lorber

   Pages 13-32

4. Listeria Genomics

   • Philippe Glaser, Christophe Rusniok, Carmen Buchrieser

   Pages 33-62

5. Metabolism and Physiology of Listeria monocytogenes

   • Jörg Slaghuis, Biju Joseph, Werner Goebel

   Pages 63-80

6. The Cell Wall of Listeria monocytogenes and its Role in Pathogenicity

   • M. Graciela Pucciarelli, Héléne Bierne, Francisco Garcìa-del Portillo

   Pages 81-110

7. Environmental Reservoir and Transmission into the Mammalian Host

   • Haley F. Oliver, Martin Wiedmann, Kathryn J. Boor

   Pages 111-137

8. Regulation of Listeria monocytogenes Virulence Genes

   • Maurine D. Miner, Gary C. Port, Nancy E. Freitag

   Pages 139-158

9. Invasion of Host Cells by Listeria monocytogenes

   • Javier Pizarro-Cerdà, Pascale Cossart

   Pages 159-176

10. Escape of Listeria monocytogenes from a Vacuole

    • Howard Goldfine, Hèléne Marquis

    Pages 177-196

11. Actin-Based Motility and Cell-to-Cell Spread of Listeria monocytogenes

    • Matthew D. Welch

    Pages 197-223

12. Adaptive Immunity to Listeria monocytogenes

    • Kelly A.N. Messingham, John T. Harty

    Pages 225-249

13. Immune Evasion and Modulation by Listeria monocytogenes

    • Lauren A. Zenewicz, Hao Shen

    Pages 251-263

14. Bacteriophages of Listeria

    • Steven Hagens, Martin J. Loessner

    Pages 265-279

15. Back Matter

    Pages 281-287

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We are at the beginning of the third decade of studies at the molecular level on the pathogenesis of Listeria monocytogenes and the response of the host to its infections. It is a good time to survey the wealth of information that these studies have revealed and to think about perspectives for a more complete understanding of this important pathogen. During the past 20 years, L. mono- togenes has emerged from relative obscurity to being one of the most intensely studied bacterial pathogens. In the opening chapter, Daniel A. Portnoy provides a personal and historical account of the development of our understanding at the molecular level of invasion of the host cell, growth in the cytosol, and ce- to-cell spread by means of actin polymerization-powered motility. We are also fortunate to have contributions from Pascale Cossart and Werner Goebel and their colleagues. These pioneering investigators continue to make major cont- butions to the molecular description of almost every aspect of L. monocytogenes pathogenesis. All chapters in this book have been written by experts who have contributed widely to this field. We are extremely grateful for the efforts of all contributors who have provided contemporary accounts of the status of various aspects of L. monocytogenes pathogenesis and the host response. Their positive responses to this effort are deeply appreciated. Any specialist volume in the biological sciences can only provide a snapshot of the field at the time of its publication.

• Immunity
• Listeria monocytogenes
• Mamma
• Pathogene
• biology
• cell biology
• host response
• infections
• physiology
• regulation
• virulence

• Department of Microbiology, University of Pennsylvania, Philadelphia, USA

  Howard Goldfine, Hao Shen

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