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This comprehensive volume, written by leading authors in the field, provides a fundamental understanding of the complex cellular and molecular processes that are important for bacterial virulence and the infectious disease process. Written in a clear and engaging manner, the book highlights key techniques and methodologies that have driven recent discoveries in bacterial pathogenesis, major structures and mechanisms in bacteria that are important for the pathogenesis of these organisms, the regulation of these virulence determinants by global regulators, and bacterial biowarfare agents. Molecular Paradigms of Infectious Disease: A Bacterial Perspective is an ideal book for students, microbiologists, immunologists and scientists and researchers of bacterial pathogenesis.
Genetic Analysis of Bacterial Pathogenesis.- Genetic Exchange in Bacteria and the Modular Structure of Mobile DNA Elements.- Genomics and the Use of Genomic Tools to Study Pathogenic Bacteria.- Pathogenicity Islands and Bacterial Virulence.- Capsules.- Bacterial Cell Walls.- Mechanisms of Bacterial Adhesion and Consequences of Attachment.- Bacterial Invasion into Non-Phagocytic Cells.- Bacterial Protein Secretion Mechanisms.- Toxins as Host Cell Modulators.- Quorum Sensing: Coordinating Group Behavior Through Intercellular Signals.- The Role of Sigma Factors in Regulating Bacterial Stress Responses and Pathogenesis.- Two-Component Regulatory Systems.- Oxidative Stress Systems in Bacteria: Four Model Organisms.- Bacterial Biowarfare Agents.