Microbial Production

1. Front Matter

   Pages i-ix

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2. Minimum Genome Factory

   1. Front Matter

      Pages 1-1

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   2. Creation of Novel Technologies for Extracellular Protein Production Toward the Development of Bacillus subtilis Genome Factories

      • Katsutoshi Ara, Kenji Manabe, Shenghao Liu, Yasushi Kageyama, Tadahiro Ozawa, Masatoshi Tohata et al.

      Pages 3-15

   3. Minimum Genome Factories in Schizosaccharomyces pombe

      • Hiromichi Kumagai, Mayumi Sasaki, Alimjan Idiris, Hideki Tohda

      Pages 17-24

   4. The Concept of the Escherichia coli Minimum Genome Factory

      • Hideharu Anazawa

      Pages 25-32

3. Whole Genome Manipulation for Genome Design

   1. Front Matter

      Pages 33-33

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   2. Efficient and Accurate Production of De Novo Designed Large-Size Gene Clusters by a Novel Bacillus subtilis-Based System

      • Mitsuhiro Itaya, Shinya Kaneko, Kenji Tsuge

      Pages 35-52

   3. Development and Application of Novel Genome Engineering Technologies in Saccharomyces cerevisiae

      • Yu Sasano, Minetaka Sugiyama, Satoshi Harashima

      Pages 53-62

   4. Genome Design of Actinomycetes for Secondary Metabolism

      • Kiyoko T. Miyamoto, Haruo Ikeda

      Pages 63-72

4. Application of Omics Information and Construction of Mutant Libraries

   1. Front Matter

      Pages 73-73

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   2. Application Methodology of Whole Omics Information

      • Myco Umemura, Masayuki Machida

      Pages 75-85

   3. Application of Genomics in Molecular Breeding of the koji Molds Aspergillus oryzae and Aspergillus sojae

      • Tadashi Takahashi

      Pages 87-95

   4. Comprehensive Libraries of Escherichia coli K-12 and Their Application

      • Hirotada Mori, Rikiya Takeuchi, Yuta Otsuka, Yong Han Tek, Wataru Nomura, Barry L. Wanner

      Pages 97-108

   5. Insights into Metabolism and the Galactose Recognition System from Microarray Analysis in the Fission Yeast Schizosaccharomyces pombe

      • Kaoru Takegawa, Tomohiko Matsuzawa

      Pages 109-118

5. Applications of Advanced Technologies for Production

   1. Front Matter

      Pages 119-119

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   2. Multi-enzymatic Systems for the Production of Chiral Compounds

      • Akira Iwasaki, Noriyuki Ito, Yoshihiko Yasohara

      Pages 121-129

   3. Use of Organic Solvent-Tolerant Microorganisms in Bioconversion

      • Akinobu Matsuyama

      Pages 131-140

   4. Approaches for Improving Protein Production by Cell Surface Engineering

      • Takeko Kodama, Kenji Manabe, Katsutoshi Ara, Junichi Sekiguchi

      Pages 141-147

   5. Strategies for Increasing the Production Level of Heterologous Proteins in Aspergillus oryzae

      • Mizuki Tanaka, Katsuya Gomi

      Pages 149-164

   6. Overproduction of l-Glutamate in Corynebacterium glutamicum

      • Hisashi Yasueda

      Pages 165-176

Microbial production: From genome design to cell surface engineering affords a comprehensive review of novel technology and approaches being implemented for manufacturing microorganisms, written by specialists in both academia and industry. This book is divided into three sections: the first includes technology for improvement of fermentation strains and many supporting technologies and information; the second examines novel technology useful for analysis of cell activities, analyzing gene function, and designing genomes of producer strains; and finally, a discussion of the practical application of the techniques and success case studies in many fields of bio-production, such as microbiological production, pharmaceuticals, chemicals, foods and cosmetics.

• Minimum genome factory
• Molecular breeding
• Omics information
• bio-production
• cell activities
• fermentation
• genome manipulation
• microorganism

• Japan Bioindustry Association, Chuo-ku, Tokyo, Japan

  Hideharu Anazawa

• Bioscience and Biotechnology, Graduate School of Environmental Science, Kyoto Gakuen University, Kameoka, Japan

  Sakayu Shimizu

Hideharu Anazawa, Ph.D., Director, Japan Bioindustry Association

Sakayu Shimizu, Ph.D., Professor, Kyoto Gakuen University

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