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Life Sciences - Evolutionary & Developmental Biology | Biological Aging - Methods and Protocols

Biological Aging

Methods and Protocols

Series: Methods in Molecular Biology, Vol. 371

Tollefsbol, Trygve O. (Ed.)

2007, XV, 414 p.

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  • New and novel techniques in biological aging research
  • Cutting-edge applications of proteomics and metabolomics
  • Identifying genes that extend lifespan using high-throughput screening systems

Biological Aging: Methods and Protocols investigates the various processes that are affected by the age of an organism. Several new tools for the analysis of biological aging have been introduced recently, and this volume provides methods and protocols for these new techniques in addition to its coverage of established procedures. The editors have carefully selected only those topics that are considered mainstays of the field or are showing promise in revolutionizing this relatively new science. The three main areas of focus in this cutting-edge compendium of biological aging research are: methods that are basic to understanding the fundamental mechanisms of cellular aging; techniques used to intervene in the aging process; and approaches to analyzing the many molecular processes of biological aging.

Researchers seeking new technology and techniques will find this volume of tremendous benefit as they move towards new directions in the exciting and expanding field of biological aging.

Content Level » Professional/practitioner

Keywords » DNA - Evolution - Microarray - Mutation - Proteomics - Telomere - Termination - age - gene transcription - genes - hybridization - saccharomyces cerevisiae - transcription

Related subjects » Cell Biology - Evolutionary & Developmental Biology - Family & Geriatric Medicine - Human Genetics

Table of contents 

Contents: Preface Contributors Techniques for Analysis of Biological Aging Trygve O. Tollefsbol Aging Cell Culture: Methods and Observations Sharla M. O. Phipps, Joel B. Berletch, Lucy G. Andrews, and Trygve O. Tollefsbol Methods to Detect Biomarkers of Cellular Senescence: The Senescence Associated b-galactosidase Koji Itahana, Judith Campisi, and Goberdhan P. Dimri Methods of Cell Sorting of Young and Senescent Cells Joao F. Passos and Thomas von Zglinicki Telomere Length Analysis Andres Canela, Peter Klatt, and Maria A. Blasco A Method to Detect DNA Methyltransferase I Gene Transcription In Vitro in Aging Systems Joel B. Berletch, Lucy G. Andrews, and Trygve O. Tollefsbol A Method to Study the Expression of DNA Methyltransferases in Aging Systems In Vitro Joel B. Berletch, Sharla M. O. Phipps, Sabrina L. Walthall, Lucy G. Andrews, and Trygve O. Tollefsbol The Chronological Life Span of Saccharomyces Cerevisiae Paola Fabrizio and Valter D. Longo Caloric Restriction and Life-Span Determination of Yeast Cells Oliver Medvedik and David A. Sinclair Methods of Nutrigenomics and Longevity Studies in Drosophila: Effects of Diets High in Sucrose, Palmitic Acid, Soy or Beef Jiatao Ye, Xiangqin Cui, Ann Loraine, Kerry Bynum, Nam Chul Kim, Gregory White, Maria De Luca, Mark D. Garfinkel, Xiangyi Lu, and Douglas M. Ruden Caloric Restriction Mimetics: A Novel Approach for Biogerontology Mark A. Lane, George S. Roth, and Donald K. Ingram Extension of Cell Life-Span Using Exogenous Telomerase Mo K. Kang and No-Hee Park Inducing Cellular Senescence Using Defined Genetic Elements Hiroshi Nakagawa and Oliver G. Opitz Methods of Induction of Cellular Senescence Using Oxidative Stresslas Hales Nuclear Transfer Methods to Study Aging Lin Liu and David L. Keefe Use of Ribozymes in Cellular Aging Research Custer C. Deocaris, Sunil C. Kaul, Kazunari Taira, and Renu Wadhwa Methods of Evaluation of Pharmacological Drugs Effects on Aging and Life Span in Mice Vladimir N. Anisimov, Irina G. Popovich, and Mark A. Zabezhinski Identifying Genes that Extend Life-Span Using a High Throughput Screening System Cuiying Chen and Roland Contreras Application of DNA Microarray Technology to Gerontological Studies Sergey V. Anisimov Detection and Analysis of Somatic Mutations at a LacZ Reporter Locus in Higher Organisms: Application to Mus Musculus and Drosophila Melanogaster Ana Maria Garcia, Rita A. Busuttil, Armando Rodriguez, Carlos Cabrera, Martha Lundell, Martijn E. T. Dolle, and Jan Vijg Subtractive Hybridization Techniques to Study Cellular Senescence Michal B. Sternberg and Shimon Gepstein Mapping Genetic Polymorphisms Affecting Natural Variation in Drosophila Longevity Maria De Luca and Jeff Leips Quantitative Trait Locus (QTL) Mapping in Aging Systems Hui-Chen Hsu, Lu Lu, Nengjun Yi, Gary Van Zant, Robert W. Williams, and John D. Mountz 2D Gel Proteomics: An Approach to Study Age-related Differences in Protein-abundance or -Isoform Complexity in Biological Samples Helen Kim, Shannon Eliuk, Jessy Deshane, Sreelatha Meleth, Todd Sanderson, Anita Pinner, Gloria Robinson, Landon Wilson, Marion Kirk, and Stephen Barnes Metabolomics in the Study of Aging and Caloric Restriction Bruce S. Kristal, Yevgeniya I. Shurubor, Rima Kaddurah- Daouk, and Wayne R. Matson Index

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