Molecular Anthropology

1. Front Matter

   Pages i-xiii

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2. Background to Some Key Issues

   1. Front Matter

      Pages 1-1

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   2. What Is Molecular Anthropology?

      • Gabriel W. Lasker

      Pages 3-12

   3. Mutation and Molecular Evolution

      • F. Vogel, M. Kopun, R. Rathenberg

      Pages 13-33

   4. The Fossil Record of Primate Phylogeny

      • Elwyn L. Simons

      Pages 35-62

   5. Splitting Times among Hominoids Deduced from the Fossil Record

      • Alan Walker

      Pages 63-77

3. Molecular Evolution as Interpreted by Mathematical Models

   1. Front Matter

      Pages 79-79

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   2. Information Theory, Molecular Evolution, and the Concepts of von Neumann

      • Lila L. Gatlin

      Pages 81-87

   3. Random and Nonrandom Processes in the Molecular Evolution of Higher Organisms

      • Richard Holmquist

      Pages 89-116

   4. Proof for the Maximum Parsimony (“Red King”) Algorithm

      • G. William Moore

      Pages 117-137

4. Primate Phylogeny and the Molecular Clock Controversy

   1. Front Matter

      Pages 139-139

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   2. Molecular Systematics of the Primates

      • Vincent M. Sarich, John E. Cronin

      Pages 141-170

   3. Immunodiffusion Evidence on the Phylogeny of the Primates

      • Howard T. Dene, Morris Goodman, William Prychodko

      Pages 171-195

   4. Evolutionary Rates in Proteins: Neutral Mutations and the Molecular Clock

      • Walter M. Fitch, Charles H. Langley

      Pages 197-219

5. Primate Evolution Inferred from Amino Acid Sequence Data

   1. Front Matter

      Pages 221-221

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   2. Evolution of the Primary Structures of Primate and Other Vertebrate Hemoglobins

      • Genji Matsuda

      Pages 223-237

   3. The Hemoglobins of Tarsius bancanus

      • Jan M. Beard, Morris Goodman

      Pages 239-255

   4. Old World Monkey Hemoglobins: Deciphering Phylogeny from Complex Patterns of Molecular Evolution

      • David Hewett-Emmett, Christopher N. Cook, N. A. Barnicot

      Pages 257-275

   5. Structure and Function of Baboon Hemoglobins

      • Bolling Sullivan, Joseph Bonaventura, Celia Bonaventura, Peter E. Nute

      Pages 277-288

   6. Evolution of Myoglobin Amino Acid Sequences in Primates and Other Vertebrates

      • A. E. Romero-Herrera, H. Lehmann, K. A. Joysey, A. E. Friday

      Pages 289-300

In 1962 at the Burg Wartenstein Symposium on "Classification and Human Evolution," Emile Zuckerkandl used the term "molecular anthropology" to characterize the study of primate phylogeny and human evolution through the genetic information contained in proteins and polynucleotides. Since that time, our knowledge of molecular evolution in primates and other organisms has grown considerably. The present volume examines this knowledge especially as it relates to the phyletic position of Homo sapiens in the order Primates and to the trends which shaped the direction of human evolution. Participants from the disciplines of protein and nucleotide chemistry, genetics, statistics, paleon­ tology, and physical anthropology held cross-disciplinary discussions and argued some of the major issues of molecular anthropology and the data upon which these arguments rest. Chief among these were the molecular clock controversy in hominoid evolution; the molecular evidence on phylogenetic relationships among primates; the evolution of gene expression regulation in primates; the relationship of fossil and molecular data in the Anthropoidea and other pri­ mates; the interpretation of the adaptive significance of evolutionary changes; and, finally, the impact on mankind of studies in molecular anthropology. Most of the papers in this volume were presented in a preliminary form at Symposium No. 65 on "Progress in Molecular Anthropology" held at Burg Wartenstein, Austria, from July 25 to August 1, 1975. These papers were subsequently revised and some additional papers related to the theme of the symposium were also contributed to this volume.

• anthropology
• evolution
• human evolution
• molecular evolution
• phylogeny
• primates

• Wayne State University School of Medicine, Detroit, USA

  Morris Goodman

• University of Michigan Medical School, Ann Arbor, USA

  Richard E. Tashian

• University of Michigan Hospital, Ann Arbor, USA

  Jeanne H. Tashian

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