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· Integrates research from a broad range of fields on primate-pathogen molecular interactions, primate immune function, and primate-pathogen co-evolution
· Provides a sound base of knowledge for future investigation of human and non-human primate evolution, immunity, and disease
· Allows the specialist and educated lay-reader to understand and critically evaluate current data on differences in the molecular mechanics of primate immune response, pathogen-mediated primate evolution, and primate health
The immune systems of humans and non-human primates have diverged such that these animals show inter- and intra-species variation in susceptibility, symptoms, and survival of particular infectious diseases. Variation in primate immunity is such that some major human pathogens - such as immunodeficiency viruses, herpesviruses and malaria-inducing species of Plasmodium - elicit striking differences in immune response between closely related species and within populations. Complex evolutionary processes that include interactions among the host, its pathogens and symbiont/commensal organisms have shaped these differences in immunity. The success of some pathogens in establishing persistent infections in humans and other primateshas been determined not just by the molecular evolution of the pathogen and its interactions with the host, but also by the evolution of primate behavior and ecology, microflora, immune factors and the evolution of other biological systems.
To explore how interactions between primates and their pathogens have shaped their mutual molecular evolution, Primates, Pathogens and Evolution brings together research that explores comparative primate immune function, the emergence of major and neglected primate diseases, primate-microorganism molecular interactions, and related topics. This book will be of interest to anyone curious as to why infectious diseases manifest differently in humans and their closest relatives. It will be of particular interest to scholars specializing in human and non-human primate evolution, epidemiology and immunology, and disease ecology. Primates, Pathogens and Evolution offers an overview and discussion of current findings on differences in the molecular mechanics of primate immune response, as well as on pathogen-mediated primate evolution and human and non-human primate health.
Section I Immunity and Primate Evolution
Vertebrate Immune system evolution and comparative primate immunity
Jessica F. Brinkworth and Mitchell Thorn
Genetic variation in the immune system of Old World monkeys: functional and selective effects
Dagan A. Loisel and Jenny Tung
Toll-like receptor function and evolution in primates
Jessica F. Brinkworth and Kirstin N. Sterner
Impact of natural selection due to malarial disease on human genetic variation
Felicia Gomez, Wen-Ya Ko, Avery Davis, and Sarah A. Tishkoff
Parasitic lice help to fill in the gaps of early hominid history
Julie M. Allen, Cedric O. Worman, Jessica E. Light, and David L. Reed
Section II Emergence and Divergent Disease Manifestation
Treponema pallidum infection in Primates: Clinical Manifestations, Epidemiology, and Evolution of a Stealthy Pathogen
Kristin Harper and Sascha Knauf
Molecular mimicry by -2 herpesviruses to modulate host cell signaling pathways
Lai-Yee Wong, Zsolt toth, Kevin F. Brulois, Kyung-Soo Inn, Sun-Hwa Lee, Hye-Ra Lee, and Jae U. Jung
Neotropical primates and their susceptibility to Toxoplasma gondii: new insights for an old problem
José Luiz Catão-Dias, Sabrina Epiphanio and Maria Cecília Martins Kierulff
The Evolution of SIV in primates and the emergence of the pathogen of AIDS
Edward JD Greenwood, Fabian Schmidt, and Jonathan L. Heeney
Section III Primates, Pathogens and Health
Microbial exposures and other early childhood influences on the subsequent function of the immune system
Graham A.W. Rook.
Make new friends and keep the old? Parasite coinfection and comorbidity in Homo sapiens
Melanie Martin, Aaron D. Blackwell, Michael Gurven and Hillard Kaplan
Primates, pathogens and evolution: A context for understanding emerging disease
Kristin N. Harper, Molly K. Zuckerman, Bethany L. Turner, George Armelagos