50 Years of Phytochemistry Research

1. Front Matter

   Pages i-xiii

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2. Metabolomics Reveals Hemiterpenoids as New Players in the Carbon–Nitrogen Economy

   • Michael H. Beale, Jane L. Ward

   Pages 1-20

3. Electrospray Ionization Traveling Wave Ion Mobility Spectrometry Mass Spectrometry for the Analysis of Plant Phenolics: An Approach for Separation of Regioisomers

   • Claudia S. Maier, Fereshteh Zandkarimi, Samanthi Wickramasekara, Jeff Morre, Jan F. Stevens

   Pages 21-41

4. Camptothecin Production and Biosynthesis in Plant Cell Cultures

   • Mami Yamazaki, Takashi Asano, Kazuki Saito

   Pages 43-54

5. Plant Defense Activators: Application and Prospects in Cereal Crops

   • Mitchell L. Wise

   Pages 55-70

6. Phytochemicals for Pest Management: Current Advances and Future Opportunities

   • Stephen O. Duke, Scott R. Baerson, Charles L. Cantrell, David E. Wedge, Kumudini M. Meepagala, Zhiqiang Pan et al.

   Pages 71-94

7. Sulfhydryl-Reactive Phytochemicals as Dual Activators of Transcription Factors NRF2 and HSF1

   • Albena T. Dinkova-Kostova, Ying Zhang, Sharadha Dayalan Naidu, Rumen V. Kostov, Ashley Pheely, Vittorio Calabrese

   Pages 95-119

8. Chemical and Biological Mechanisms of Phytochemical Activation of NRF2 and Importance in Disease Prevention

   • Aimee L. Eggler, Sergey N. Savinov

   Pages 121-155

9. Back Matter

   Pages 157-159

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This 43rd volume of RAP includes a total of seven articles based on talks presented at the 50th Anniversary meeting of the PSNA, which was held at the Fairmont Orchid, in Waikoloa, Hawai’i, USA. These seven Perspectives give a very good picture of the breadth of plant (bio)chemistry research in North America, which is also indicative of the state of the field worldwide. Each of these articles describes the integration of several different approaches to ask and then answer interesting questions regarding the function of interesting plant metabolites, either in the plant itself or in interactions with the environment (natural setting or human health application).   Two Perspectives outline very clearly the power of approaching biological questions from a modern, “omics” or systems biology approach. Beale and Ward outline how metabolomics approaches can be brought to bear on plant biosynthetic questions and quickly lead to important advances in our understanding or how plants produce important metabolites. Zandkarimi et al. outline the integration of ion mobility spectrometry into mass spectrometry-based metabolomics investigations and show clearly how powerful those two spectrometric technologies can be when used together. ​

• Camptothecin production
• Electrospray ionization
• Metabolomics
• Sulfhydryl-reactive phytochemicals
• plant phenolics

• Institute of Biological Chemistry, Washington State University, Pullman, USA

  David R. Gang

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