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Modern cell biology has brought improvements in therapy for advanced malignant diseases through immunomodulation, hematopoietic stem cell transplantation, and other advanced techniques. Collected here are selected papers from the Fifth International Symposium of Keio University for Life Sciences and Medicine on Cell Therapy. All chapters include innovative basic research for clinical application: immunotherapy, cancer vaccination, molecular biology of hematopoietic stem cells, stem cell processing, and gene therapy. The book is divided into three parts: Immunotherapy for malignant diseases; Hematopoietic stem cell biology and clinical application; and International collaboration in hematopoietic stem cell transplantation. Included in the third part is information on bone marrow registries from around the world. The book thus presents up-to-date information on biological and clinical aspects of treatment, with insight into the future of cell therapy.
Content Level »Research
Keywords »Carcinom - Vivo - bone - bone marrow tranplantation - cell biology - cells - gene therapy - hematopoietic stem cell - immunotherapy
Part 1 Immunotherapy for Malignant Diseases: Breaking immunologic tolerance to tumor cells as a novel immunotherapy for cancer - Sakaguchi. SART1 Gene Encoding Squamous Cell Carcinoma Antigen Recognized by Cytotoxic T Lymphocytes - Itoh. Adoptive Immunotherapy of Human Diseases with Antigen-Specific T Cell Clones - Riddell. Adoptive Transfer of Polyclona, EBV-Specific Cytotoxic T Cell Lines for the Prevention and Treatment of EBV-Associated Malignancies - Rooney. Processing of Antigens by Dendritic Cells: Nature's Adjuvant - Inaba. Immunotherapy of Melanoma using Dendritic Cells - Nestle. Immunotherapy of Melanoma Using T Cell Defined Angigens - Kawakami.- Part 2 Hematopoietic Stem Cell: Biology and Clinical Application: Isolation and Characterization of CD34-Low/Negative Mouse Hematopoietic Stem Cells - Nakauchi. Abstract: Ex Vivo Expansion of Human Hematopoietic Stem Cells - Nakahata. Notch in Hematopoiesis: Cell Fate Decisions and Self-Renewal of progenitors - Milner. Molecular Genetics of Acute Promyelocytic Leukemia: a rationale for 'transcription therapy' for cancer Pandolfi A Novel Acute Promyelocytic Leukemia Model: from Cell to Murine System - Kizaki. Phase 1 Trial of Retroviral-mediated Transfer of the Human MDR1 in Patients undergoing High-dose Chemotherapy and Autologous Stem Cell Transplantation - Hesdorffer. Basic Studies Toward Hamatopoietic Stem Cell Gene Therapy - Hanazono. EX VIVO EXPANSION OF HEMATOPOIETIC CELLS - McNiece. Harnessing Graft vs Leukemia without Myeloablative Therapy - Giralt. Ex vivo expansion of human cord blood stem cells and genetic manipulation - Ando.- Part 3 International Collaboration of Hematopoietic Stem Cell Transplantation: Abstract: Unrelated Donor Stem Cell Transplantation: A registry Perspective - Howe. European Bone Marrow Donor Registries Collaboration and Individualism - Egeland. Abstract: Asian Bone Marron Donor Registries: Their Roles in International Cooperation - Okamoto. Cord Blood Stem Cell Transplantation: Banking and Clinical Results - Gluckman.