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Sphingolipid Biology

  • Book
  • © 2006

Overview

Editors:
  1. Yoshio Hirabayashi

    1. Brain Science Institute, The Institute of Physical and Chemical Research (Riken), Saitama, Japan

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  2. Yasuyuki Igarashi

    1. Department of Biomembrane and Biofunctional Chemistry, Faculty of Advanced Life Science and Graduate School of Life Science, Hokkaido University, Sapporo, Japan

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  3. Alfred H. Merrill

    1. School of Biology and the Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, USA

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Table of contents (39 chapters)

  1. Front Matter

    Pages i-xxvi
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  2. Overview

    1. Front Matter

      Pages 1-1
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    2. Sphingolipids Synthesis, Transport and Cellular Signaling

      • Yoshio Hirabayashi, Yasuyuki Igarashi, Alfred H. Merrill Jr.
      Pages 3-22

  3. Biosynthesis, Transport of Sphingolipids

    1. Front Matter

      Pages 23-23
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    2. Serine Palmitoyltransferase

      • Jia Wei, Tokumbo Yerokun, Martina Liepelt, Amin Momin, Elaine Wang, Kentaro Hanada et al.
      Pages 25-47

    3. Ceramide Synthase

      • Irene Pankova-Kholmyansky, Anthony H. Futerman
      Pages 49-56

    4. Dihydroceramide: Sphinganine Δ4-Desaturase and C4-Hydroxylase

      • Akemi Suzuki, Fumio Omae, Ayako Enomoto
      Pages 57-68

    5. Metabolizing Enzymes Such As Sphingomyelin Synthase Induce Cell Death by Increasing Ceramide Content

      • Toshiro Okazaki
      Pages 69-81

    6. Glucosylceramide and Galactosylceramide Synthase

      • James A. Shayman
      Pages 83-94

    7. Synthesis, Metabolism, and Trans-Bilayer Movement of Long-Chain Base

      • Akio Kihara, Yasuyuki Igarashi
      Pages 95-106

    8. Molecular Mechanism of Ceramide Trafficking from the Endoplasmic Reticulum to the Golgi Apparatus in Mammalian Cells

      • Kentaro Hanada, Miyuki Kawano, Keigo Kumagai
      Pages 107-121

    9. Sphingolipid Trafficking

      • Kouichi Funato, Howard Riezman
      Pages 123-139

    10. Current Perspectives on Saccharomyces cerevisiae Sphingolipids

      • Robert C. Dickson, Robert L. Lester
      Pages 141-150

  4. Generation and Degradation of Sphingolipid Signaling Molecules

    1. Front Matter

      Pages 151-151
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    2. Generation of Signaling Molecules by De Novo Sphingolipid Synthesis

      • Kazuyuki Kitatani, L. Ashley Cowart, Yusuf A. Hannun
      Pages 153-165

    3. Overview of Acid and Neutral Sphingomyelinases in Cell Signaling

      • Youssef Zeidan, Norma Marchesini, Yusuf A. Hannun
      Pages 167-181

    4. Neutral Ceramidase as an Integral Modulator for the Generation of S1P and S1P-Mediated Signaling

      • Makoto Ito, Motohiro Tani, Yukihiro Yoshimura
      Pages 183-196

    5. Activation of Sphingosine Kinase 1

      • Michael Maceyka, Sergio E. Alvarez, Sheldon Milstien, Sarah Spiegel
      Pages 197-206

    6. Ceramide 1-Phosphate

      • Susumu Mitsutake, Tack-Joong Kim, Yasuyuki Igarashi
      Pages 207-218

    7. Sphingosine-1-Phosphate Lyase

      • Julie D. Saba
      Pages 219-230
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Keywords

About this book

Sphingolipids are fundamental to the structures of cell membranes, lipoproteins, and the stratum cornea of the skin. Many complex sphingolipids as well as simpler sphingoid bases and derivatives are highly bioactive as extra- and intracellular regulators of growth, differentiation, migration, survival, senescence, and numerous cellular responses to stress. This book provides many examples of exciting new developments in sphingolipid biology/sphingolipidology that are changing our understanding of how multicellular organisms grow, develop, function, age, and die. Key areas addressed include sphingolipid biosynthesis, transport and membrane organization/lipid rafts; genetic approaches to understanding the roles of membrane sphingolipid biosynthesis; sphingolipid metabolism, specific G protein-coupled receptors (GPCRs), and signal transduction; and sphingolipid-associated disease and drug development.

Editors and Affiliations

  • Brain Science Institute, The Institute of Physical and Chemical Research (Riken), Saitama, Japan

    Yoshio Hirabayashi

  • Department of Biomembrane and Biofunctional Chemistry, Faculty of Advanced Life Science and Graduate School of Life Science, Hokkaido University, Sapporo, Japan

    Yasuyuki Igarashi

  • School of Biology and the Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, USA

    Alfred H. Merrill

Bibliographic Information

  • Book Title: Sphingolipid Biology

  • Editors: Yoshio Hirabayashi, Yasuyuki Igarashi, Alfred H. Merrill

  • DOI: https://doi.org/10.1007/4-431-34200-1

  • Publisher: Springer Tokyo

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag Tokyo 2006

  • Hardcover ISBN: 978-4-431-34198-7Published: 19 July 2006

  • Softcover ISBN: 978-4-431-54666-5Published: 02 December 2014

  • eBook ISBN: 978-4-431-34200-7Published: 31 December 2007

  • Edition Number: 1

  • Number of Pages: XXV, 531

  • Topics: Cell Biology, Biochemistry, general

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