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Non-viral Gene Therapy

Gene Design and Delivery

  • Book
  • © 2005

Overview

Editors:
  1. Kazunari Taira

    1. Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan
      Gene Function Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Science City, Japan

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  2. Kazunori Kataoka

    1. Department of Materials Science and Engineering, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan

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  3. Takuro Niidome

    1. Department of Applied Chemistry, Faculty of Engineering, Kyushu University, Fukuoka, Japan

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  • Covers chemical aspects such as design and synthesis of gene carriers, as well as knowledge from in vivo experiments and clinical aspects of non-viral gene therapy

  • Complementary information of this book, such as movies, experimental data, etc. will be introduced and updated in the web page of The Japanese Society of Gene Design and Delivery

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Table of contents (36 chapters)

  1. Front Matter

    Pages I-XII
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  2. Molecules for Gene Therapy

    1. Front Matter

      Pages 1-1
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    2. Recent Progress in Non-viral Gene Delivery

      • Christine C. Conwell, Leaf Huang
      Pages 3-10

    3. Physical Chemistry of DNA-Carrier Complexes

      • Kenichi Yoshikawa, Yuko Yoshikawa
      Pages 11-18

    4. Liposomes

      • Kazuo Maruyama
      Pages 19-34

    5. Polymeric Gene Carriers

      • Tomoko Hashimoto, Tetsuji Yamaoka
      Pages 35-50

    6. Development of a Supramolecular Nanocarrier for Gene Delivery Based on Cationic Block Copolymers

      • Yuichi Yamasaki, Woo-Dong Jang, Nobuhiro Nishiyama, Naoki Kanayama, Kazunori Kataoka
      Pages 51-62

    7. Chitosan

      • Mayu Hashimoto, Zhihong Yang, Yohei Koya, Toshinori Sato
      Pages 63-74

    8. Dendrimers as DNA Carriers

      • Hidetoshi Arima
      Pages 75-86

    9. Use of Synthetic Peptides for Non-viral Gene Delivery

      • Takuro Niidome, Yoshiki Katayama
      Pages 87-102

    10. An Oligonucleotide Carrier Based on β-1,3-Glucans

      • Kazuo Sakurai, Seiji Shinkai
      Pages 103-117

    11. Biological and Chemical Hybrid Vectors

      • Mahito Nakanishi
      Pages 118-132

  3. Controlled Gene Delivery

    1. Front Matter

      Pages 133-133
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    2. Pharmacokinetics of Gene Delivery in Cells

      • Hidetaka Akita, Ikramy A. Khalil, Kentaro Kogure, Hideyoshi Harashima
      Pages 135-154

    3. Active DNA Release from Complexes

      • Takeshi Nagasaki
      Pages 155-164

    4. Controlled Release of DNA Using Thermoresponsive Polymers

      • Masayuki Yokoyama
      Pages 165-175

    5. Active Transport of Exogenous Genes into the Nucleus

      • Takeshi Kawazu, Takeshi Nagasaki
      Pages 176-186

    6. Controlled Intracellular Localization of Oligonucleotides by Chemical Conjugation

      • Takanori Kubo, Rumiana Bakalova, Zhivko Zhelev, Hideki Ohba, Masayuki Fujii
      Pages 187-197

    7. Functional Nucleotide Sequences Capable of Promoting Non-viral Genetic Transfer

      • Osam Mazda, Tsunao Kishida
      Pages 198-210

    8. Shielding of Cationic Charge of the DNA Complex to Avoid Nonspecific Interactions for In Vivo Gene Delivery

      • Yoshiyuki Koyama
      Pages 211-225
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Keywords

Editors and Affiliations

  • Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan

    Kazunari Taira

  • Gene Function Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Science City, Japan

    Kazunari Taira

  • Department of Materials Science and Engineering, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan

    Kazunori Kataoka

  • Department of Applied Chemistry, Faculty of Engineering, Kyushu University, Fukuoka, Japan

    Takuro Niidome

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