Myocardial Preconditioning

1. Front Matter

   Pages N2-XIII

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2. Preconditioning Against Myocardial Infarction—Its Features and Adenosine-Mediated Mechanism

   • Tetsuji Miura

   Pages 1-17

3. Does Preconditioning Reduce Lethal Mechanical Reperfusion Injury?

   • David García-Dorado, Marisol Ruiz-Meana, José A. Barrabés

   Pages 19-34

4. Ischemic Preconditioning Markedly Reduces the Severity of Ischemia and Reperfusion-Induced Arrhythmias: Role of Endogenous Myocardial Protective Substances

   • Agnes Vegh, James R. Parratt

   Pages 35-60

5. The Protective Effects of Preconditioning on Postischemic Contractile Dysfunction

   • Alison C. Cave

   Pages 61-78

6. Reduction of Infarct Size— “Preconditioning at a Distance”

   • Karin Przyklenk, Peter Whittaker, Michel Ovize, Robert A. Kloner

   Pages 79-96

7. Novel Approaches to Myocardial Preconditioning in Pigs

   • Ben C. G. Gho, Monique M. G. Koning, René L. J. Opstal, Eric van Klaarwater, Dirk J. Duncker, Pieter D. Verdouw

   Pages 97-113

8. Preconditioning in the Human Heart: Fact or Fantasy?

   • Clive S. Lawson

   Pages 115-128

9. Role of ATP-Sensitive Potassium Channels in Myocardial Preconditioning

   • Gary J. Grover

   Pages 129-146

10. The Role of G Proteins in Myocardial Preconditioning

    • Lucia Piacentini, Nigel J. Pyne

    Pages 147-166

11. Mimicking Preconditioning with Catecholamines

    • Tanya Ravingerová

    Pages 167-184

12. Activation of Protein Kinase C is Critical to the Protection of Preconditioning

    • Michael V. Cohen, Yongge Liu, James M. Downey

    Pages 185-206

13. The Mechanism of Preconditioning—What Have We Learned from the Different Animal Species?

    • Cherry L. Wainwright, Wei Sun

    Pages 207-232

14. Myocardial Stress Response, Cytoprotective Proteins and the Second Window of Protection Against Infarction

    • Gary F. Baxter, Michael S. Marber, Derek M. Yellon

    Pages 233-250

15. Delayed Ischemic Preconditioning Induced by Drugs and by Cardiac Pacing

    • Agnes Vegh, James R. Parratt

    Pages 251-260

16. Cardioprotective Effects of Chronic Hypoxia: Relation to Preconditioning

    • František Kolář

    Pages 261-275

17. Back Matter

    Pages 277-285

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This book is about the unique ability of the heart to protect itself against the serious consequences of an abrupt reduction in blood flow to the myocardium - a phenomenon which is switched on by stress and termed myocardial preconditioning. This volume describes the main features and characteristics of preconditioning, with respect to the time-course of the protective effect of the phenomenon (first and second windows) and the different sequelae of myocardial ischaemia against which it protects, such as myocardial injury, arrhythmias and contractile dysfunction. The proposed mechanisms underlying the fascinating form of cardioprotection are discussed. Among these are the role of endogenous labile mediators, receptor-linked G proteins, ATP-sensitive potassium channels and protein kinase C activation.

• activation
• potassium
• protein
• proteins
• receptor

• Department of Physiology and Pharmacology, University of Strathclyde, Royal College, Glasgow, Scotland

  Cherry L. Wainwright, James R. Parratt

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