Softcover reprint of the original 1st ed. 1999, XIII, 330 p.
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This is the first book to take an interdisciplinary approach to genomic imprinting
This book provides an unrivalled in-depth treatise of genomic imprinting, a phenomenon which plays a vital role in many biological processes in developmental biology, evolution and human diseases and genetics. The reason for this broad range of influence derives from the fact that genomic imprinting shields a number of important genes from the full effects of Mendelian inheritance. The importance of this surprising observation, which was discovered less than two decades ago, has been only slowly recognized. The reason for this may be that genomic imprinting is a difficult concept to understand. This book aims at providing interesting, entertaining and detailed information for any scientist, irrespective of their particular field of study.
General Aspects.- Kinship and Genomic Imprinting. Genommic Imprinting in Plants. Imprinting and Paternal Genome Elimination in Insects. Imprinting and X-Chromosome Inactivation. Mechanisms of Genomic Imprinting. Human Diseases and Genomic Imprinting. Genomic Imprinting and Cancer.Players of Imprinting.- The Mechanisms of Transcriptional Regulation- Epigenetic Control of Gene Expression. Polycomb Silencing and the Maintenance of Stable Chromatin States. Domains and Boundaries in Chromosomes. A Role for Modifier Genes in Genome Imprinting. Allelic Trans-Sensing and Imprinting. Nuclear Architecture. Imprinted Genes and Regions in Mouse and Human.