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Regulation of Alternative Splicing

  • Book
  • © 2003

Overview

Editors:
  1. Philippe Jeanteur

    1. Institute of Molecular Genetics of Montpellier, CNRS, Montpellier Cedex 05, France

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  • Excellent overview of alternative splicing
  • Incorporates newly emerging technologies and research directions
  • Includes supplementary material: sn.pub/extras

Part of the book series: Progress in Molecular and Subcellular Biology (PMSB, volume 31)

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Table of contents (8 chapters)

  1. Front Matter

    Pages I-XIII
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  2. Prediction and Statistical Analysis of Alternatively Spliced Exons

    • T. A. Thanaraj, S. Stamm
    Pages 1-31

  3. Multiple Roles of the SR Protein Family in Splicing Regulation

    • J. R. Sanford, D. Longman, J. F. Cáceres
    Pages 33-58

  4. Heterogeneous Nuclear Ribonucleoprotein Particle A/B Proteins and the Control of Alternative Splicing of the Mammalian Heterogeneous Nuclear Ribonucleoprotein Particle A1 Pre-mRNA

    • B. Chabot, C. LeBel, S. Hutchison, F. H. Nasim, M. J. Simard
    Pages 59-88

  5. Phosphorylation-Dependent Control of the Pre-mRNA Splicing Machinery

    • J. Soret, J. Tazi
    Pages 89-126

  6. Splicing Regulation in Drosophila Sex Determination

    • P. Förch, J. Valcárcel
    Pages 127-151

  7. Alternative Pre-mRNA Splicing and Regulation of Programmed Cell Death

    • J. Y. Wu, H. Tang, N. Havlioglu
    Pages 153-185

  8. Alternative Pre-mRNA Splicing and Neuronal Function

    • D. L. Black, P. J. Grabowski
    Pages 187-216

  9. Modulation of Alternative Splicing by Antisense Oligonucleotides

    • P. Sazani, R. Kole
    Pages 217-239

  10. Back Matter

    Pages 241-245
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Keywords

About this book

The discovery in 1977 that genes are split into exons and introns has done away with the one gene - one protein dogma. Indeed, the removal of introns from the primary RNA transcript is not necessarily straightforward since there may be optional pathways leading to different messenger RNAs and consequently to different proteins. Examples of such an alternative splicing mechanism cover all fields of biology. Moreover, there are plenty of occurrences where deviant splicing can have pathological effects. Despite the high number of specific cases of alternative splicing, it was not until recently that the generality and extent of this phenomenon was fully appreciated. A superficial reading of the preliminary sequence of the human genome published in 2001 led to the surprising, and even deceiving to many scientists, low number of genes (around 32,000) which contrasted with the much higher figure around 150,000 which was previously envisioned. Attempts to make a global assessment of the use of alternative splicing are recent and rely essentially on the comparison of genomic mRNA and EST sequences as reviewed by Thanaraj and Stamm in the first chapter of this volume. Most recent estimates suggest that 40-60% of human genes might be alternatively spliced, as opposed to about 22% for C. elegans.

Editors and Affiliations

  • Institute of Molecular Genetics of Montpellier, CNRS, Montpellier Cedex 05, France

    Philippe Jeanteur

Bibliographic Information

  • Book Title: Regulation of Alternative Splicing

  • Editors: Philippe Jeanteur

  • Series Title: Progress in Molecular and Subcellular Biology

  • DOI: https://doi.org/10.1007/978-3-662-09728-1

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2003

  • Hardcover ISBN: 978-3-540-43833-5Published: 21 October 2002

  • Softcover ISBN: 978-3-642-07858-3Published: 01 December 2010

  • eBook ISBN: 978-3-662-09728-1Published: 14 March 2013

  • Series ISSN: 0079-6484

  • Series E-ISSN: 2197-8484

  • Edition Number: 1

  • Number of Pages: XIII, 245

  • Number of Illustrations: 77 b/w illustrations, 1 illustrations in colour

  • Topics: Cell Biology, Biochemistry, general, Developmental Biology, Animal Genetics and Genomics

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