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Life Sciences - Cell Biology | Intracellular Antibodies - Development and Applications

Intracellular Antibodies

Development and Applications

Cattaneo, Antonino, Biocca, Silvia (Eds.)

Jointly published with Landes Bioscience, Georgetown, USA

Softcover reprint of the original 1st ed. 1997, XIII, 196 p.

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  • About this book

  • This is the first book to describe how antibodies can be exploited to block biological functions or to confer new phenotypic traits (e.g. resistance to a virus).
Recent advances in the field of recombinant antibodies have permitted the manipulation of genes encoding specific antibodies, thus allowing their ectopic expression in a wide variety of non-lymphoid cells. This volume describes how the ectopic expression of antibodies, as secreted or as intracellularly retargeted molecules, can be exploited to block biological functions or to confer new phenotypic traits (e.g. resistance to a virus). This is the first book describing this emerging technology, which is receiving increasing attention for application in many different fields and biological systems - from human gene therapy to plant biotechnology.

Content Level » Professional/practitioner

Keywords » Antik├Ârper - Expression - Genexpression - Immunologie - antibody - biotechnology - diseases - gene - gene expression - gene therapy - immunology - infectious disease - protein - resistance - virus

Related subjects » Biotechnology - Cell Biology - Immunology - Molecular Medicine

Table of contents 

1. Intracellular and Intercellular Immunization.- 2. Current Methods for Genotypic and Phenotypic Knock-Outs in Mammalian Cells.- 3. Recombinant Antibodies for Ectopic Expression.- 4. Assembly and Folding of Antibodies in Natural and Artificial Environments.- 5. Protein Sequence Motifs Involved in Intracellular Trafficking.- 6. Intercellular Immunization.- 7. Intracellular Immunization.- 8. Gene Therapy and Research Applications of Intrabodies for Human Infectious Diseases.- 9. Plantibodies: Immunomodulation and Immunotherapeutic Potential.- 10. From Phage Libraries to Intracellular Immunization.- 11. Perspectives and Conclusions.

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