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Life Sciences - Cell Biology | Protein Degradation in Health and Disease

Protein Degradation in Health and Disease

Reboud-Ravaux, Michele (Ed.)

Softcover reprint of the original 1st ed. 2002, X, 130 p.

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ISBN 978-3-642-56373-7

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  • About this book

  • A concise overview of protein degradation, unique in its perspective on both fundamental mechanisms and implications for medical research
Protein degradation has been identified as a centerpiece of regulation of cell functions. Not surprisingly, its deregulation is implied in almost any pathological condition. This book describes how aged proteins are eliminated during cell metabolism, how cell proliferation is regulated by protein degradation and how its deregulation can contribute to the development of cancer, how protein degradation is modified during normal and abnormal aging, in particular with regard to Alzheimer's disease and other degenerative diseases of the brain and central nervous system. Attempts aiming at correcting these pathologies by interfering with deviations of the normal pathway of protein degradation are also treated.

Content Level » Research

Keywords » Krebs - Proteinabbau - aging - alzheimer's disease - cancer - cell - central nervous system - development - diseases - metabolism - pathology - proliferation - protein - proteins - regulation

Related subjects » Biochemistry & Biophysics - Cancer Research - Cell Biology

Table of contents 

Roles of SCF and VHL Ubiquitin Ligases in Regulation of Cell Growth.- Aging of Proteins and the Proteasome.- Protein Degradation in the Aging Organism.- Protein Degradation in Alzheimer’s Disease and Aging of the Brain.- Protein Degradation in Human Disease.- The 26S Proteasome.- Proteasome Inhibitors.

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