Softcover reprint of the original 1st ed. 2004, XVI, 342 p.
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Describes molecular pathways controlled by viral genes and how research in this area opens opportunities in cancer therapy
Uses different viral models to analyze molecular pathways regulated by viral genes and their role in the pathogenesis of infection
Explores particular cell types in apoptosis, such as neuronal cells and lymphoid cells
When a virus infects a cell the virus takes control of cellular functions to its advantage. The cell counteracts with its defensive immune system and stress responses. Both sides of this struggle bring about modifications in the cell death program, which is crucial for the infection outcome.
In this book, molecular pathways regulated by viral genes and their role in the pathogenesis of infection are analyzed using different viral models. The book also offers an update of known signaling pathways in apoptosis and their role in normal and infected cells. Special emphasis is given to molecular pathways underlying viral transformation and oncogenesis and how research in this area is opening opportunities in cancer therapy. Particular cell types in apoptosis, such as neuronal cells and lymphoid cells, are also explored.
This book provides an in-depth update of viral gene interactions with regulation pathways in apoptosis for scientists and researchers in molecular biology, virology, cell biology, oncology, and neurobiology.
Cell Death Suppressors Encoded by Cytomegalovirus.- Apoptosis Regulator Genes Encoded by Poxviruses.- T-Cell-Mediated Control of Poxvirus Infection in Mice.- Switching On and Off the Cell Death Cascade: African Swine Fever Virus Apoptosis Regulation.- Neuronal Apoptosis Pathways in Sindbis Virus Encephalitis.- Apoptotic Pathways Triggered By HIV and Consequences on T Cell Homeostasis and HIV-Specific Immunity.- HIV and Apoptosis: a Complex Interaction Between Cell Death and Virus Survival.- Poliovirus and Apoptosis.- Flaviviruses and Apoptosis Regulation.- Manipulation of Apoptosis by Herpes Viruses (Kaposi’s Sarcoma Pathogenesis).- Exploitation of Cell Cycle and Cell Death Controls by Adenoviruses: The Road to a Productive Infection.- Induction of Transformed Cell-Specific Apoptosis by the Adenovirus E4orf4 Protein.- Epstein-Barr Virus Signal Transduction and B-Lymphocyte Growth Transformation.- SV40 and Notch-I: Multi-functionality Meets Pleiotropy.- Signal Transduction and Apoptosis Pathways as Therapeutic Targets.